方案
≥95% (HPLC)
表单
lyophilized
组成
Peptide Content, ≥75%
储存条件
protect from light
储存温度
−20°C
Amino Acid Sequence
Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Met-Val-Lys-Ser-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Lys-Ala-Phe-NH2
应用
β-降钙素基因相关肽（β-CGRP）通过G偶联蛋白受体（GCPR）降钙素受体样受体（CALCRL）调节心血管稳态和伤害感受。
CGRP II 8-37可用作CGRP受体拮抗剂。
CGRP II 8-37可用作CGRP受体拮抗剂。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
监管及禁止进口产品
Joseph J Lynch et al.
European journal of pharmacology, 623(1-3), 96-102 (2009-09-22)
The triptans, serotonin 5-HT(1B/1D) receptor agonists exemplified by sumatriptan, are a mainstay migraine therapy but have class labeling contraindicating their use in patients with coronary artery disease. Triptans constrict human coronary artery in vitro, and there are case reports of
Toomas Talme et al.
Journal of neuroimmunology, 196(1-2), 60-66 (2008-04-22)
CGRP significantly stimulated migration of non-activated and anti-CD3 activated T lymphocytes into a collagen matrix when present inside the collagen, whereas somatostatin-14, NPY, substance P, VIP, beta-endorphin and metenkephalin had no or little effect. The CGRP antagonist CGRP 8-37 abrogated
Jean-Olivier Zirimwabagabo et al.
Journal of medicinal chemistry, 64(6), 3299-3319 (2021-03-06)
Class B G-protein-coupled receptors (GPCRs) remain an underexploited target for drug development. The calcitonin receptor (CTR) family is particularly challenging, as its receptors are heteromers comprising two distinct components: the calcitonin receptor-like receptor (CLR) or calcitonin receptor (CTR) together with
I-Ching Hou et al.
Peptides, 30(12), 2228-2232 (2009-09-02)
We found that beta-lactotensin (His-Ile-Arg-Leu), which has been isolated as an ileum-contracting peptide from chymotrypsin digest of bovine beta-lactoglobulin, dose-dependently suppresses food intake after intracerebroventricular (i.c.v.) or intraperitoneal administration at a dose of 40 nmol/mouse or 100mg/kg, respectively, in fasted
Vince T Nguyen et al.
Peptides, 33(1), 77-82 (2011-11-24)
Cardiac epinephrine and calcitonin gene-related peptide (CGRP) are produced by intrinsic cardiac adrenergic cells (ICA cells) residing in human and animal hearts. ICA cells are neuroparicine cells expressing δ-opioid receptors (DOR). We hypothesized that δ-opioid stimulation of ICA cells enhances
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