产品名称
cAMP依赖性蛋白激酶抑制剂PKI-tide,
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥67%
storage condition
protect from light
storage temp.
−20°C
Application
IAAGRTGRRQAIHDILVAA用作cAMP依赖性蛋白激酶抑制肽。
Biochem/physiol Actions
cAMP依赖性蛋白激酶抑制剂通常被设计为靶向第二信使cAMP(环磷酸腺苷)的合成和降解。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design
Taylor SS, et al.
Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics, 1784(1), 16-26 (2008)
Barbara Wienen-Schmidt et al.
ChemMedChem, 16(1), 292-300 (2020-10-09)
In lead optimization, protein crystallography is an indispensable tool to analyze drug binding. Binding modes and non-covalent interaction inventories are essential to design follow-up synthesis candidates. Two protocols are commonly applied to produce protein-ligand complexes: cocrystallization and soaking. Because of
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