方案
≥94% (HPLC)
表单
lyophilized
组成
Peptide Content, ≥80%
储存条件
protect from light
储存温度
−20°C
Amino Acid Sequence
Ac-Leu-Asp-Glu-Ser-Asp-al
应用
Caspase 2/3 Inhibitor (Ac-LDESD-CHO) is used to study the active site recognition of penta5 (P5) position substrates by caspases 2 and 3.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Guoxing Fu et al.
Apoptosis : an international journal on programmed cell death, 13(11), 1291-1302 (2008-09-10)
Caspase-3, -6 and -7 cleave many proteins at specific sites to induce apoptosis. Their recognition of the P5 position in substrates has been investigated by kinetics, modeling and crystallography. Caspase-3 and -6 recognize P5 in pentapeptides as shown by enzyme
Andreas Schweizer et al.
The Journal of biological chemistry, 278(43), 42441-42447 (2003-08-16)
The cell death protease caspase-2 has recently been recognized as the most apical caspase in the apoptotic cascade ignited during cell stress signaling. Cytotoxic stress, such as that caused by cancer therapies, leads to activation of caspase-2, which acts as
Ling Wang et al.
Cancer research, 68(12), 4640-4648 (2008-06-19)
Kaposi's sarcoma-associated herpesvirus (KSHV) is associated with three different human malignancies, including Kaposi's sarcoma (KS), primary effusion lymphoma, and multicentric Castleman's disease. The KS lesion is of endothelial cell in origin and is highly dependent on autocrine and paracrine factors
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