assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥55%
storage condition
protect from light
storage temp.
−20°C
General description
组织蛋白酶L抑制剂是一种组蛋白H3加工酶。它在维持表皮稳态、毛囊正常形态发生和周期中起重要作用。组织蛋白酶L参与蛋白降解。它可能会调节免疫系统的正常功能。组织蛋白酶L可调节巨噬细胞死亡、坏死核心形成和动脉粥样硬化斑块不稳定进展。
Application
组织蛋白酶L是一种可代谢胶原蛋白和弹性蛋白的溶酶体半胱氨酸蛋白酶。组织蛋白酶L的作用和活性可借助肽抑制剂如五肽酰胺RKLLW-NH2（Arg-Lys-Leu-Leu-Trp-NH2）而得以研究。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
A Brinker et al.
European journal of biochemistry, 267(16), 5085-5092 (2000-08-10)
By screening a combinatorial pentapeptide amide collection in an inhibition assay, we systematically evaluated the potential of 19 proteinogenic amino acids and seven nonproteinogenic amino acids to serve as building blocks for inhibitors of human cathepsin L. Particularly efficient were
Protease signalling: the cutting edge
Turk B, et al.
The Embo Journal, 31(7), 1630-1643 (2012)
Cathepsin L is significantly associated with apoptosis and plaque destabilization in human atherosclerosis
Li W, et al.
Atherosclerosis, 202(1), 92-102 (2009)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SCP0110-5MG | 04061833024850 |