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Merck
CN

SCP0134

Sigma-Aldrich

Endothelin Antagonist PD 142893

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关于此项目

经验公式(希尔记法):
C50H65N7O10
分子量:
924.09
UNSPSC代码:
12352200
NACRES:
NA.32
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方案

≥95% (HPLC)

表单

lyophilized

组成

Peptide Content, ≥85%

储存条件

protect from light

储存温度

−20°C

Amino Acid Sequence

Acl-Dif-Leu-Asp-Ile-Ile-Trp

应用

PD 142-893 is used as a nonselective endothelin ET(A)/ET(B) receptor antagonist.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Chumpon Wilasrusmee et al.
Surgery, 134(2), 384-389 (2003-08-30)
We have previously shown that endothelial injury by cyclosporin A (CyA) is associated with an increased endothelin-1 (ET-1) release. We now sought to determine, in an animal model of angiogenesis, if inhibiting the effect of ET-1 on endothelial cells (ECs)
Ashley M Stokes et al.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 70(3), 197-205 (2006-07-21)
The goals of this study were to determine the concentration-response (C-R) relationship of endothelin-1 (ET-1), compare 2 ET-receptor antagonists and determine the antagonist concentrations that block the vasomotor effects of ET-1, and compare the effectiveness of ET-1 and previously studied
Sebastien Faure et al.
Journal of vascular research, 43(1), 19-26 (2005-10-29)
The effect of angiotensin IV (AngIV) was studied in freshly isolated rat basilar arteries (BAs) perfused at a constant rate. AngIV had no effect on basal BA perfusion pressure, but induced a marked concentration-dependent contraction in vessels precontracted by a
Alexandra Madsen et al.
Journal of molecular and cellular cardiology, 154, 115-123 (2021-02-15)
The role of DNA methylation in cardiomyocyte physiology and cardiac disease remains a matter of controversy. We have recently provided evidence for an important role of DNMT3A in human cardiomyocyte cell homeostasis and metabolism, using engineered heart tissue (EHT) generated

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