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SCP0135

Endothelin β Receptor Agonist IRL 1620

Name: Endothelin β Receptor Agonist IRL 1620
Brand: SIGMA

别名:

Endothelin Agonist, Endothelin Receptor Agonist

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关于此项目

经验公式（希尔记法）:

C₈₆H₁₁₆N₁₇O₂₇

分子量:

1819.94

NACRES:

NA.32

UNSPSC Code:

12352200

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属性

assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥80%

storage condition

protect from light

solubility

1 mg/mL at in water (Add acetonitrile dropwise to solution in water, mixing until the peptide dissolves)

storage temp.

−20°C

说明

Application

IRL-1620 is used as a specific endothelin-B receptor (ET(B)-R) agonist.

pictograms

GHS06

signalword

Danger

hcodes

H300 + H330

pcodes

P260 - P264 - P270 - P271 - P284 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

AE0414

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Endothelin B receptor agonist, IRL-1620, reduces neurological damage following permanent middle cerebral artery occlusion in rats.

Mary G Leonard et al.

Brain research, 1420, 48-58 (2011-10-01)

Endothelin and its receptors have long been considered therapeutic targets in the treatment of ischemic stroke. Recent studies indicate that ET(B) receptors may provide both vasodilatation and neuroprotection. The purpose of this study was to determine the effect of selectively

IRL-1620, an endothelin-B receptor agonist, enhanced radiation induced reduction in tumor volume in Dalton's Lymphoma Ascites tumor model.

A Gulati et al.

Arzneimittel-Forschung, 62(1), 14-17 (2012-02-15)

ETB receptor agonist, IRL-1620 (or SPI-1620) presently in US Phase 1 clinical trial, has been demonstrated to selectively and transiently increase tumor blood flow. The present study was conducted to determine the effect of IRL-1620 on radiation therapy in tumor

Activation of the ET-1/ETA pathway contributes to erectile dysfunction associated with mineralocorticoid hypertension.

Fernando S Carneiro et al.

The journal of sexual medicine, 5(12), 2793-2807 (2008-10-01)

The cavernosal tissue is highly responsive to endothelin-1 (ET-1), and penile smooth muscle cells not only respond to but also synthesize ET-1. Considering that ET-1 is directly involved in end-organ damage in salt-sensitive forms of hypertension, we hypothesized that activation

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全球贸易项目编号

货号	GTIN
SCP0135-1MG	04061826693490
SCP0135-500UG	04061833025000