assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥80%
storage condition
protect from light
solubility
1 mg/mL at in water (Add acetonitrile dropwise to solution in water, mixing until the peptide dissolves)
storage temp.
−20°C
Application
IRL-1620 is used as a specific endothelin-B receptor (ET(B)-R) agonist.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 1 Inhalation - Acute Tox. 1 Oral
存储类别
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Fernando S Carneiro et al.
The journal of sexual medicine, 5(12), 2793-2807 (2008-10-01)
The cavernosal tissue is highly responsive to endothelin-1 (ET-1), and penile smooth muscle cells not only respond to but also synthesize ET-1. Considering that ET-1 is directly involved in end-organ damage in salt-sensitive forms of hypertension, we hypothesized that activation
Mary G Leonard et al.
Brain research, 1420, 48-58 (2011-10-01)
Endothelin and its receptors have long been considered therapeutic targets in the treatment of ischemic stroke. Recent studies indicate that ET(B) receptors may provide both vasodilatation and neuroprotection. The purpose of this study was to determine the effect of selectively
A Gulati et al.
Arzneimittel-Forschung, 62(1), 14-17 (2012-02-15)
ETB receptor agonist, IRL-1620 (or SPI-1620) presently in US Phase 1 clinical trial, has been demonstrated to selectively and transiently increase tumor blood flow. The present study was conducted to determine the effect of IRL-1620 on radiation therapy in tumor
Manish S Lavhale et al.
Pharmacological research, 62(6), 489-499 (2010-09-10)
Clonidine decreases mean arterial pressure (MAP) by acting as an α(2)-adrenergic receptor (AR) agonist in the central nervous system; it also acts on peripheral α-ARs to produce vasoconstriction. Endothelin (ET) has been shown to modulate the action of ARs. The
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