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Merck
CN

SCP0136

Endothelin β Receptor Antagonist IRL 1038

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关于此项目

经验公式(希尔记法):
C68H92N14O15S2
分子量:
1409.67
NACRES:
NA.32
UNSPSC Code:
12352200
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assay

≥95% (HPLC)

form

lyophilized

composition

Peptide Content, ≥67%

storage condition

protect from light

storage temp.

−20°C

Application

IRL-1038 is used as a specific endothelin-B receptor (ET(B)-R) antagonist/blocker.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Noreen F Rossi
American journal of physiology. Endocrinology and metabolism, 286(4), E535-E541 (2003-12-11)
The endothelins (ET) have been implicated in vasopressin (AVP) release in vivo and in vitro. The effects of ET in this system are complex, and the net AVP secretory response likely depends on a unique combination of ET isoform, ET
Hung-Tien Kuo et al.
The Kaohsiung journal of medical sciences, 22(8), 371-376 (2006-08-17)
Angiotensin II (Ang-II) is a potent vasoactive hormone, which plays an important role in the pathogenesis of glomerulosclerosis. Ang-II activates many cytokine systems in the kidney. Recent studies indicate that Ang-II is closely related to the activation of the endothelin-1
Changaram S Venugopal et al.
Canadian journal of veterinary research = Revue canadienne de recherche veterinaire, 70(1), 50-57 (2006-03-22)
The purpose of this study was to evaluate the role of endothelin-1 (ET-1) and its receptors in the airway hyperreactivity of horses with obstructive pulmonary disease associated with summer pasture (SPAOPD). The right diaphragmatic lobe of the lung of 8
Guo-lin Zhang et al.
Acta pharmacologica Sinica, 32(2), 223-229 (2011-02-05)
To investigate which endothelin receptors mediated isoproterenol (ISO)-induced downregulation of FKBP12.6/12 in cardiomyocytes and study whether argirhein, a novel compound containing rhein and L-arginine that has anti-inflammatory activity, could reverse the downregulation of FKBP12.6/12 induced by ISO. Neonatal rat cardiomyocytes

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