方案
≥95% (HPLC)
表单
lyophilized
组成
Peptide Content, ≥85%
储存条件
protect from light
储存温度
−20°C
Amino Acid Sequence
Glu-Ala-Val-Leu-Trp
应用
Endothelin Receptor Antagonist W-7338A isolated from Streptomyces sp. No. 7338 is used as an endothelin receptor antagonist.
储存分类代码
11 - Combustible Solids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
S Miyata et al.
The Journal of antibiotics, 45(1), 83-87 (1992-01-01)
WS-7338, produced by Streptomyces sp. No. 7338, was found to be a competitive and specific antagonist against ET-1 receptors in in vitro studies and WS-7338 B is also active in vivo. Furthermore, WS-7338 B was a specific antagonist for vascular
WS-7338, new endothelin receptor antagonists isolated from Streptomyces sp. No. 7338. III. Structures of WS-7338 A, B, C and D and total synthesis of WS-7338 B.
S Miyata et al.
The Journal of antibiotics, 45(5), 788-791 (1992-05-01)
Endothelin receptor antagonists: an overview of their synthesis and structure-activity relationship.
Javed Iqbal et al.
Mini reviews in medicinal chemistry, 5(4), 381-408 (2005-04-28)
Endothelins (ETs) are potent vasoconstrictor peptides and are associated with several disease states like pulmonary hypertension, systemic hypertension and heart failure. Endothelin-1 (ET-1) is the first member of the family and it has the receptor subtypes known as ETA and
S Miyata et al.
The Journal of antibiotics, 45(1), 74-82 (1992-01-01)
WS-7338 A, B, C and D, novel endothelin receptor antagonists, have been isolated from fermentation broth of Streptomyces sp. No. 7338. These antagonists were purified from the culture mycelium by extraction with acetone, followed by carbon column chromatography and HPLC.
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