Merck
CN
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文件

安全信息

SCP0138

Sigma-Aldrich

BQ-3020

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别名:
Acetyl-(Ala 11,15)-ET 1 (6-21), Acetyl-[Ala 11,15]-endothelin 1 (6-21), BQ 3020, endothelin receptor antagonist
经验公式（希尔记法）:
C96H140N20O25S1
CAS号:
143113-45-5
分子量:
2006.32
NACRES:
NA.32

检测方案

≥95% (HPLC)

形式

lyophilized

组成

Peptide Content, ≥75%

储存条件

protect from light

UniProt登记号

P05305

储存温度

−20°C

InChI

1S/C93H136N20O23S/c1-15-51(9)77(91(133)110-72(93(135)136)40-58-44-96-62-27-21-20-26-61(58)62)113-92(134)78(52(10)16-2)112-89(131)71(43-75(119)120)108-85(127)66(37-49(5)6)105-87(129)69(41-59-45-95-47-98-59)104-79(121)54(12)100-83(125)67(38-56-24-18-17-19-25-56)106-86(128)68(39-57-29-31-60(115)32-30-57)109-90(132)76(50(7)8)111-80(122)53(11)99-73(116)46-97-81(123)63(28-22-23-34-94)102-88(130)70(42-74(117)118)107-82(124)64(33-35-137-14)103-84(126)65(36-48(3)4)101-55(13)114/h17-21,24-27,29-32,44-45,47-54,63-72,76-78,96,115H,15-16,22-23,28,33-43,46,94H2,1-14H3,(H,95,98)(H,97,123)(H,99,116)(H,100,125)(H,101,114)(H,102,130)(H,103,126)(H,104,121)(H,105,129)(H,106,128)(H,107,124)(H,108,127)(H,109,132)(H,110,133)(H,111,122)(H,112,131)(H,113,134)(H,117,118)(H,119,120)(H,135,136)/t51-,52-,53-,54-,63-,64-,65-,66-,67-,68-,69-,70-,71-,72-,76-,77-,78-/m0/s1

InChI key

NUAGCEFLVCODRQ-KETPNHLCSA-N

Gene Information

human ... EDN1(1906)

Amino Acid Sequence

Ac-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp

生化/生理作用

BQ-3020, a linear endothelin analog, is a selective ETB endothelin receptor agonist.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险声明

H300 + H330

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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A novel radioligand [125I]BQ-3020 selective for endothelin (ETB) receptors.
Ihara M
Life Sciences, 51(6) (1992)
A. Bjorklund
Peptides (New York, NY, United States) (2000)
Najam A Sharif et al.
Current eye research, 36(5), 462-468 (2011-04-20)
The receptor-coupled signal transduction systems present in isolated human choroidal melanocytes (HCOMs) were investigated. [(3)H]-inositol phosphates ([(3)H]-IPs) generated in the cells were measured by ion-exchange chromatography. cAMP generated in the cells was quantified using an enzyme immunoassay. Initially, HCOM cells
Akira Hirose et al.
Current eye research, 32(6), 585-591 (2007-07-07)
The physiological properties of endothelin-1 in ocular choroidal melanocytes are not well-known, although endothelin-1 increases the intracellular calcium concentration through endothelin-B receptors in skin melanocytes. We studied the effect of endothelin-1 on choroidal melanocytes in rabbit ocular suprachoroidal tissue. Fura-2
José Luis Arteaga et al.
Neurourology and urodynamics, 31(5), 688-694 (2012-03-31)
The involvement of endothelin receptors in the contraction of the lower urinary tract smooth muscle is well established. There is scarce information, however, about endothelin receptors mediating relaxation of the bladder outlet region. The current study investigates the possible existence
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