assay
≥92% (HPLC)
form
lyophilized
composition
Peptide Content, ≥75%
storage condition
protect from light
storage temp.
−20°C
General description
Gastrin, a classic digestive hormone, is found in three major forms: gastrin-34 (big gastrin), gastrin-17 (little gastrin), and gastrin-13 (minigastrin). Mammalian gastrin consists of a C-terminal four amino-acid sequence and a sulfated tyrosine 7 residue from the C-terminus. Gastrin is mostly found in the G cells of the stomach mucosa. Nutrients and gastrin-releasing peptides stimulate the release of gastrin.
Application
Gastrin I (1-14) has been used:
- as a component of gastric cancer stem/progenitor cell (GCSPC) medium for tumorsphere culture
- as a supplement in organoid growth medium (OGM) for patient-derived organoid (PDO)
- in viable lymphocytes culture for re-stimulation assay
Biochem/physiol Actions
The peptide gastrin I (1-14), which lacks a basic site, forms positive ions. Gastrin promotes the production and liberation of histamine in enterochromaffin-like cells through cholecystokinin 2 receptor (CCK2R). It also stimulates the release of gastric acid in parietal cells via the CCK2R receptor. Gastrin plays a key role in Zollinger-Ellison syndrome. It may play a role in the development of colorectal carcinoma.
Gastrin is a linear polypeptide that induces the secretion of gastric acid (HCl) by parietal cells.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable