产品名称
Granulocyte Elastase Substrate human,
assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥85%
storage condition
protect from light
storage temp.
−20°C
General description
Elastase, a glycoprotein, is a member of the serine proteases family. It is synthesized by human polymorphonuclear (PMN) leukocytes or by the pancreas. Human granulocyte elastase is liberated in large amounts from granulocytes in chronic inflammatory joint disorders.
Biochem/physiol Actions
Elastase is a catalytic enzyme that catalyzes the cleavage of carboxyl groups on tiny hydrophobic amino acids including glycine, alanine, and valine. Its main function is to break down elastin. Free elastase in some purulent synovial fluids plays a key role in articular cartilage breakdown. Increased elastase levels in the plasma have been seen in patients with evident rheumatoid arthritis.
Elastase(s) can be assayed and differentiated using chromogenic and fluorogenic Pro-Val peptide substrates such as Glp-Pro-Val-pNA and MeOSuc-Ala-Ala-Pro-Val-4-MNA.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Evaluation of exocrine pancreatic function
Cotton SW
Contemporary Practice in Clinical Chemistry, 573-585 (2020)
Use of Extracts from Squirting Cucumber (Ecballium elaterium) Seeds in Health
Attard E
Nuts and Seeds in Health and Disease Prevention, 1079-1086 (2011)
Effects of Nigella (Nigella sativa L.) Seed Extract on Human Neutrophil Elastase Activity
Kacem R
Nuts and Seeds in Health and Disease Prevention, 823-829 (2011)
K Kleesiek et al.
Rheumatology international, 6(4), 161-169 (1986-01-01)
Human granulocyte elastase (EC 3.4.21.37) is released from granulocytes in large amounts in chronic inflammatory joint diseases and is therefore of special pathogenic and diagnostic importance. In order to examine the diagnostic significance of this enzyme as a clinico-chemical parameter
Pier Carlo Braga et al.
Pharmacology, 77(3), 150-154 (2006-07-11)
Erdosteine is a mucolytic drug whose metabolization gives rise to an active metabolite with an SH group (Met I), which reduces neutrophil release of reactive oxygen species and the peroxynitrite generated by the reaction of superoxide anion with nitric oxide
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