SMB00075
(−)-Arctigenin
别名:
2（3H）-呋喃酮, （3,4）-4-[（3,4-二甲氧基苯基）甲基]二氢-3-[（4-羟基-3-甲氧基苯基）甲基]-2（3H）-呋喃酮
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关于此项目
经验公式（希尔记法）:
C21H24O6
化学文摘社编号:
分子量:
372.41
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:
InChI
1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1
SMILES string
COc1cc(C[C@@H]2[C@H](COC2=O)Cc3ccc(OC)c(OC)c3)ccc1O
InChI key
NQWVSMVXKMHKTF-JKSUJKDBSA-N
form
solid
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
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General description
牛蒡苷元是牛蒡根中的一种木脂素。它已用于药理、化妆品、研究，显示了几种抗病毒和抗癌作用。
Biochem/physiol Actions
二苄基丁内酯配体、天然产物、病毒整合酶和拓扑异构酶II 抑制剂、抗氧化剂、抗病毒剂、抗炎剂、免疫调节剂。
存储类别
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
Shengrong Sun et al.
Planta medica, 77(2), 141-145 (2010-08-19)
The involvement of unfolded protein response (UPR) activation in tumor survival and resistance to chemotherapies suggests a new anticancer strategy targeting UPR pathway. Arctigenin, a natural product, has been recently identified for its antitumor activity with selective toxicity against cancer
Ji Yun Lee et al.
Archives of pharmacal research, 33(6), 947-957 (2010-07-08)
We previously reported that arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan isolated from Forsythia koreana, exhibits anti-inflammatory, antioxidant, and analgesic effects in animal models. In addition, arctigenin inhibited eosinophil peroxidase and activated myeloperoxidase in inflamed tissues. In this study, we tested the
Vivek Swarup et al.
The Journal of antimicrobial chemotherapy, 61(3), 679-688 (2008-01-31)
OBJECTIVES; To evaluate therapeutic efficacy of arctigenin in an experimental model of Japanese encephalitis (JE). Four- to 5-week-old BALB/c mice of either sex were infected intravenously with lethal dose of 3 x 10(5) pfu of Japanese encephalitis virus (JEV). By
Suresh Awale et al.
Cancer research, 66(3), 1751-1757 (2006-02-03)
Tumor cells generally proliferate rapidly and the demand for essential nutrients as well as oxygen always exceeds the supply due to the unregulated growth and the insufficient and inappropriate vascular supply. However, cancer cells show an inherent ability to tolerate
Ju-Young Kim et al.
Journal of cellular physiology, 224(1), 33-40 (2010-03-17)
Cancer cells in poorly vascularized solid tumors are constantly or intermittently exposed to stressful microenvironments, including glucose deprivation, hypoxia, and other forms of nutrient starvation. These tumor-specific conditions, especially glucose deprivation, activate a signaling pathway called the unfolded protein response
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