SMB00172
Tephrosin
≥95% (LC/MS-ELSD)
别名:
Deguelinol I, Hydroxydeguelin
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关于此项目
经验公式（希尔记法）:
C23H22O7
化学文摘社编号:
分子量:
410.42
MDL编号:
UNSPSC代码:
12352205
PubChem化学物质编号:
NACRES:
NA.25
方案
≥95% (LC/MS-ELSD)
表单
solid
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
SMILES字符串
COc1cc2OC[C@H]3Oc4c(ccc5OC(C)(C)C=Cc45)C(=O)[C@@]3(O)c2cc1OC
InChI
1S/C23H22O7/c1-22(2)8-7-12-15(30-22)6-5-13-20(12)29-19-11-28-16-10-18(27-4)17(26-3)9-14(16)23(19,25)21(13)24/h5-10,19,25H,11H2,1-4H3/t19-,23-/m1/s1
InChI key
AQBZCCQCDWNNJQ-AUSIDOKSSA-N
一般描述
Natural product derived from plant source.
生化/生理作用
Tephrosin is a plant-based rotenoid which has known anti-cancer properties. Tephrosin inhibited proliferation in A549 cancer cells in a dose-sependent manner. Tephrosin has been shown to induce capase-independent apoptosis, and internalization and degradation of inactivated EGFR and ErB2 in human colon cancer cells.
警示用语：
Warning
危险声明
预防措施声明
危险分类
Aquatic Acute 1 - Aquatic Chronic 1
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Abiy Yenesew et al.
Pest management science, 59(10), 1159-1161 (2003-10-17)
A crude chloroform extract of seeds of Millettia dura Dunn (Leguminosae) showed high activity (LC50 = 3.5 microg ml(-1) at 24 h) against second-instar larvae of the mosquito, Aedes aegypti L (Diptera: Culicidae). The rotenoids, deguelin and tephrosin, isolated from
Sujin Choi et al.
Cancer letters, 293(1), 23-30 (2010-01-09)
Inactivation of epidermal growth factor receptor (EGFR) family members are prime targets for cancer therapy. Here, we show that tephrosin, a natural rotenoid which has potent antitumor activities, induced internalization of EGFR and ErbB2, and thereby induced degradation of the
Shugeng Cao et al.
Journal of natural products, 67(3), 454-456 (2004-03-27)
Bioassay-guided fractionation of methanolic extracts of Mundulea chapelieri resulted in the isolation of two new flavonoids, isomundulinol (1) and 3-deoxy-MS-II (2), in addition to the eight known flavonoids 8-(3,3-dimethylallyl)-5,7-dimethoxyflavanone, MS-II, mundulinol, mundulone, munetone, rotenolone, rotenone, and tephrosin, and one known
Xueling Qu et al.
African journal of traditional, complementary, and alternative medicines : AJTCAM, 10(3), 458-468 (2013-10-23)
As the traditional Chinese medicine, the fresh fruits of Amorpha fruticosa L. were applied for the treatment of carbuncle, eczema and burn (Das et al., 2007). However, little is known about the functional roles of the fruits of Amorpha fruticosa
Haoyu Ye et al.
Journal of chromatography. A, 1178(1-2), 101-107 (2007-12-18)
Both analytical and preparative high-speed counter-current chromatography (HSCCC) were used to isolate and separate chemical bioactive constituents from the seeds of Millettia pachycarpa Benth, a famous traditional Chinese medicine. Three rotenoids and one isoflavone were successfully purified for the first
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