SMB00348
人参皂苷化合物 K
≥96% (HPLC)
别名:
(3B,12B)-3,12-二羟基达马-24-烯-20-基 β-D-吡喃葡萄糖苷, 20 (S)-人参皂苷 Ck, 人参皂苷 K, 原人参二醇 20-O-葡萄糖苷
质量水平
方案
≥96% (HPLC)
表单
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
SMILES字符串
CC(C)=CCC[C@](C1C2[C@H](O)CC3[C@@]([C@]2(C)CC1)(C)CCC4C(C)(C)[C@@H](O)CC[C@@]43C)(C)O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O
InChI
1S/C36H62O8/c1-20(2)10-9-14-36(8,44-31-30(42)29(41)28(40)23(19-37)43-31)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(39)32(3,4)24(33)12-17-34(25,35)6/h10,21-31,37-42H,9,11-19H2,1-8H3/t21?,22-,23-,24?,25?,26+,27?,28-,29+,30-,31+,33+,34-,35-,36+/m1/s1
InChI key
FVIZARNDLVOMSU-KJULZEBLSA-N
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一般描述
人参皂苷化合物K是在人参根中发现的一种四环达玛烷型三萜皂苷。它是人参的主要成分，人参传统上用于增加对压力和衰老的抵抗力。
应用
- Combination of Electrochemistry and Mass Spectrometry to Study Nitric Oxide Metabolism and Its Modulation by Compound K in Breast Cancer Cells.：本文联合电化学和质谱技术，研究乳腺癌细胞中人参皂苷化合物K与一氧化氮代谢的相互作用，阐明代谢途径和化合物K的潜在治疗作用(Zhao et al., 2022)。
- Metabolic analysis of Panax notoginseng saponins with gut microbiota-mediated biotransformation by HPLC-DAD-Q-TOF-MS/MS.：本文探讨肠道菌群介导的三七总皂苷（包括化合物K）生物转化，详述生物系统复杂的相互作用和代谢特征，有助了解它们的治疗用途和生物利用度(Chen et al., 2018)。
生化/生理作用
人参皂苷化合物K具有很多药理性质，包括抗糖尿病、抗炎、肝脏保护、抗过敏和抗癌作用。它在大鼠中也具有神经保护性质，可以从突触丧失和记忆损害中恢复。人参皂苷化合物K可以抑制人脐静脉内皮细胞（HUVEC）中多种基因表达，从而抑制内皮细胞的迁移和血管生成。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Effects of sphingolipid metabolism disorders on endothelial cells.
Lai, et al.
Lipids in Health and Disease, 21, 101-101 (2022)
Alzheimer's Disease as a Major Public Health Concern: Role of Dietary Saponins in Mitigating Neurodegenerative Disorders and Their Underlying Mechanisms.
Abduljawad, et al.
Molecules (Basel), 27 (2022)
Xi-Ding Yang et al.
Fitoterapia, 100, 208-220 (2014-12-03)
As an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, ginsenoside compound K (20-O-beta-d-glucopyranosyl-20(S)-protopanaxadiol, CK) is a major deglycosylated metabolite form of ginsenosides which is absorbed into the systemic circulation. And it has demonstrated such diverse intriguing biological properties as anticarcinogenic
Catherine Hu et al.
European journal of pharmacology, 815, 501-511 (2017-10-17)
Conflicting data exist on the effect of ginsenosides on transactivation of human glucocorticoid receptor α (herein referred to as glucocorticoid receptor), and relatively little is known regarding the effect of these chemicals on transrepression of this receptor. We investigated the
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