SMB00348
人参皂苷化合物 K
≥96% (HPLC)
别名:
(3B,12B)-3,12-二羟基达马-24-烯-20-基 β-D-吡喃葡萄糖苷, 20 (S)-人参皂苷 Ck, 人参皂苷 K, 原人参二醇 20-O-葡萄糖苷
质量水平
方案
≥96% (HPLC)
表单
powder
应用
metabolomics
vitamins, nutraceuticals, and natural products
SMILES字符串
CC(C)=CCC[C@](C1C2[C@H](O)CC3[C@@]([C@]2(C)CC1)(C)CCC4C(C)(C)[C@@H](O)CC[C@@]43C)(C)O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O
InChI
1S/C36H62O8/c1-20(2)10-9-14-36(8,44-31-30(42)29(41)28(40)23(19-37)43-31)21-11-16-35(7)27(21)22(38)18-25-33(5)15-13-26(39)32(3,4)24(33)12-17-34(25,35)6/h10,21-31,37-42H,9,11-19H2,1-8H3/t21?,22-,23-,24?,25?,26+,27?,28-,29+,30-,31+,33+,34-,35-,36+/m1/s1
InChI key
FVIZARNDLVOMSU-KJULZEBLSA-N
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一般描述
人参皂苷化合物K是在人参根中发现的一种四环达玛烷型三萜皂苷。它是人参的主要成分，人参传统上用于增加对压力和衰老的抵抗力。
应用
- Combination of Electrochemistry and Mass Spectrometry to Study Nitric Oxide Metabolism and Its Modulation by Compound K in Breast Cancer Cells.：本文联合电化学和质谱技术，研究乳腺癌细胞中人参皂苷化合物K与一氧化氮代谢的相互作用，阐明代谢途径和化合物K的潜在治疗作用(Zhao et al., 2022)。
- Metabolic analysis of Panax notoginseng saponins with gut microbiota-mediated biotransformation by HPLC-DAD-Q-TOF-MS/MS.：本文探讨肠道菌群介导的三七总皂苷（包括化合物K）生物转化，详述生物系统复杂的相互作用和代谢特征，有助了解它们的治疗用途和生物利用度(Chen et al., 2018)。
生化/生理作用
人参皂苷化合物K具有很多药理性质，包括抗糖尿病、抗炎、肝脏保护、抗过敏和抗癌作用。它在大鼠中也具有神经保护性质，可以从突触丧失和记忆损害中恢复。人参皂苷化合物K可以抑制人脐静脉内皮细胞（HUVEC）中多种基因表达，从而抑制内皮细胞的迁移和血管生成。
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Effects of sphingolipid metabolism disorders on endothelial cells.
Lai, et al.
Lipids in Health and Disease, 21, 101-101 (2022)
Xi-Ding Yang et al.
Fitoterapia, 100, 208-220 (2014-12-03)
As an intestinal bacterial metabolite of ginseng protopanaxadiol saponins, ginsenoside compound K (20-O-beta-d-glucopyranosyl-20(S)-protopanaxadiol, CK) is a major deglycosylated metabolite form of ginsenosides which is absorbed into the systemic circulation. And it has demonstrated such diverse intriguing biological properties as anticarcinogenic
Alzheimer's Disease as a Major Public Health Concern: Role of Dietary Saponins in Mitigating Neurodegenerative Disorders and Their Underlying Mechanisms.
Abduljawad, et al.
Molecules (Basel), 27 (2022)
Catherine Hu et al.
European journal of pharmacology, 815, 501-511 (2017-10-17)
Conflicting data exist on the effect of ginsenosides on transactivation of human glucocorticoid receptor α (herein referred to as glucocorticoid receptor), and relatively little is known regarding the effect of these chemicals on transrepression of this receptor. We investigated the
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