SMB00370
四氢姜黄素
≥96% (HPLC)
别名:
四氢姜黄素, 1,7-双（4-羟基-3-甲氧基苯基）-3,5-庚二酮, HZIV 81-2, NSC687845, 四氢呋喃基甲烷
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关于此项目
经验公式（希尔记法）:
C21H24O6
化学文摘社编号:
分子量:
372.41
UNSPSC Code:
12352205
NACRES:
NA.25
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
3485469
InChI
1S/C21H24O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h5-6,9-12,24-25H,3-4,7-8,13H2,1-2H3
SMILES string
COc1cc(CCC(=O)CC(=O)CCc2ccc(O)c(OC)c2)ccc1O
InChI key
LBTVHXHERHESKG-UHFFFAOYSA-N
assay
≥96% (HPLC)
form
powder
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
Quality Level
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General description
四氢姜黄素(THC)是姜黄素的无色代谢产物。结构与姜黄素类似。THC的化学结构中不含α, β-不饱和羰基。是来源于莪术(Curcuma zedoaria)、姜笋(Zingiber mioga)和姜(Zingiber officinale)根部的天然产物。
Application
四氢姜黄素(THC)已作为神经保护剂，研究其在缺血性中风小鼠模型中改善线粒体功能障碍的治疗潜力。
Biochem/physiol Actions
四氢姜黄素的治癌作用经过充分研究，具有出色的抗癌、抗血管生成和化学预防活性。还具有抗炎性。已发现四氢姜黄素可通过缓解氧化应激发挥针对糖尿病和血管功能障碍的抗氧化和保护作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
385.2 °F
flash_point_c
196.2 °C
Bharat B Aggarwal et al.
Molecules (Basel, Switzerland), 20(1), 185-205 (2014-12-31)
Curcumin (diferuloylmethane), a golden pigment from turmeric, has been linked with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antidiabetic properties. Most of the these activities have been assigned to methoxy, hydroxyl, α,β-unsaturated carbonyl moiety or to diketone groups present in curcumin.
Sunmin Park et al.
Genes & nutrition, 11, 2-2 (2016-08-03)
Menopausal symptoms are associated with inflammation. Curcumin is a well-known anti-inflammatory bioactive compound from turmeric whereas tetrahydrocurcumin (THC) is a major metabolite of curcumin that may have different efficacies. However, they have not been studied for anti-menopausal symptoms and anti-osteoarthritis
Ching-Shu Lai et al.
Biomolecules, 10(6) (2020-06-04)
In recent decades, cancer has been one of the leading causes of death worldwide. Despite advances in understanding the molecular basis of tumorigenesis, diagnosis, and clinical therapies, the discovery and development of effective drugs is an active and vital field
Jia-Ching Wu et al.
Food & function, 5(1), 12-17 (2013-11-14)
Chemoprevention is a relatively new and promising strategy to prevent human degenerative diseases, including cancer, and is defined as the use of natural dietary compounds and/or synthetic substances to block, inhibit, reverse, or retard the progress of human diseases. Tetrahydrocurcumin
Upa Kukongviriyapan et al.
The Tohoku journal of experimental medicine, 239(1), 25-38 (2016-05-07)
Cadmium (Cd) is a non-essential heavy metal with high toxicity potential. Humans are exposed to Cd present in diet, polluted air, and cigarette smoke. Cd exposure has been associated with increased risk of chronic diseases, including hypertension, atherosclerosis, diabetes, and
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