SMB00387
Prothionamide
≥99% (HPLC)
别名:
Prothionamide, 2-propyl-4-pyridinecarbothioamide, 2-propylisonicotinylthioamide, 2-propylthioisonicotinamide, 2-Propyl-4-pyridinecarbothioamide, 2-Propylisonicotinylthioamide
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关于此项目
经验公式（希尔记法）:
C9H12N2S
化学文摘社编号:
分子量:
180.27
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
MDL number:
Quality Segment
assay
≥99% (HPLC)
form
powder
color
yellow
antibiotic activity spectrum
mycobacteria
mode of action
enzyme | interferes
storage temp.
−20°C
SMILES string
NC(C1=CC(CCC)=NC=C1)=S
InChI
1S/C9H12N2S/c1-2-3-8-6-7(9(10)12)4-5-11-8/h4-6H,2-3H2,1H3,(H2,10,12)
InChI key
VRDIULHPQTYCLN-UHFFFAOYSA-N
General description
Chemical structure: pyridine
Prothionamide is an analogue of ethionamide, and is better tolerated and less toxic than ethionamide. It contains a propyl group instead of an ethyl group at the α position.
Biochem/physiol Actions
Prothionamide is the second line of drug used in leprosy and in tuberculosis. It is highly effective against Mycobacterium tuberculosis. In patients with multidrug-resistant tuberculosis (MDR-TB), prothionamide causes the development of hepatitis. In rare cases, it causes drug reaction with eosinophilia and systemic symptoms (DRESS) in patients with MDR-TB. DRESS is characterized by fever, hematologic abnormalities, skin eruption, and internal organ disruption.
Preparation Note
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510) Non Combustible liquids.
Other Notes
Keep container tightly closed in a dry and well-ventilated place. Storage class (TRGS 510): Non Combustible Solids
