SMB00515
Afzelin
≥90% (LC/MS-UV)
别名:
3,4′,5,7-四羟基黄酮 3-鼠李糖甙, Afzeloside, 山柰酚, 山柰酚3-O-α-L-鼠李糖甙, 山柰酚3-鼠李糖甙
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关于此项目
经验公式（希尔记法）:
C21H20O10
化学文摘社编号:
分子量:
432.38
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352205
MDL number:
产品名称
Afzelin, ≥90% (LC/MS-UV)
InChI key
SOSLMHZOJATCCP-AEIZVZFYSA-N
SMILES string
OC1=CC(O)=C(C(C(O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)=C(C3=CC=C(O)C=C3)O4)=O)C4=C1
InChI
1S/C21H20O10/c1-8-15(25)17(27)18(28)21(29-8)31-20-16(26)14-12(24)6-11(23)7-13(14)30-19(20)9-2-4-10(22)5-3-9/h2-8,15,17-18,21-25,27-28H,1H3/t8-,15-,17+,18+,21-/m0/s1
assay
≥90% (LC/MS-UV)
form
solid
solubility
DMSO: 1 mg/mL
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
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Application
保护DNA、抗氧化、抗炎、吸收紫外线和抗菌活性。Afzelin已用于高效液相色谱法(HPLC)分析，以检测复方蒿提取物中的主要成分。
Biochem/physiol Actions
Afzelin是NOS抑制剂和NADPH氧化酶抑制剂，具有抗菌、抗炎、抗凋亡和抗肿瘤活性。Afzelin可作为铜绿假单胞菌相关疾病的有效治疗药物。Afzelin还能促进乳腺癌细胞凋亡，抑制细胞增殖。在小鼠模型中表现出抗哮喘作用。
General description
Afzelin来源于植物的天然产物。黄酮类醇苷Afzelin的主要来源为掌叶榕和香睡莲。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Seoung Woo Shin et al.
PloS one, 8(4), e61971-e61971 (2013-04-30)
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Kashchenko N, et al.
Molecules (Basel), 22(1), 73-73 (2017)
Afzelin attenuates asthma phenotypes by downregulation of GATA3 in a murine model of asthma
Zhou Wenbo and Nie Xiuhong
Molecular Medicine Reports, 12(1) (2015)
Sang Yeol Lee et al.
Molecules (Basel, Switzerland), 19(3), 3173-3180 (2014-03-20)
The crude ethyl acetate extract of the leaves of Cornus macrophylla showed antibacterial activity against Pseudomonas aeruginosa, a leading cause of illness in immunocompromised individuals. Bioactivity-guided separation led to the isolation of kaempferol 3-O-α-L-rhamnopyranoside (afzelin). The structure was determined based
Parham Taslimi
Journal of biochemical and molecular toxicology, 34(11), e22566-e22566 (2020-07-03)
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