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SMB00576

薯蓣皂甙

Name: 薯蓣皂甙
Brand: SIGMA

≥95% (HPLC)

别名:

薯蓣皂苷元双-α-L-鼠李吡喃糖基-（1→2,1→4）-β-D-吡喃葡萄糖苷, 重楼皂甙 III, 重楼皂苷 III

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经验公式（希尔记法）:

C₄₅H₇₂O₁₆

化学文摘社编号:

19057-60-4

分子量:

869.04

NACRES:

NA.25

PubChem Substance ID:

329825065

UNSPSC Code:

12352205

MDL number:

MFCD02094174

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属性

Quality Level

200

assay

≥95% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

SMILES string

C[C@@]12[C@]([C@@H]3C)([H])[C@](O[C@]34CC[C@@H](C)CO4)([H])C[C@@]1([H])[C@@](CC=C5[C@@]6(CC[C@H](O[C@@](O[C@H](CO)[C@@H](O[C@@](O[C@@H](C)[C@H](O)[C@H]7O)([H])[C@@H]7O)[C@@H]8O)([H])[C@@H]8O[C@@](O[C@@H](C)[C@H](O)[C@H]9O)([H])[C@@H]9O)C5)C)([H])[C@]6([H]

InChI

1S/C45H72O16/c1-19-9-14-45(54-18-19)20(2)30-28(61-45)16-27-25-8-7-23-15-24(10-12-43(23,5)26(25)11-13-44(27,30)6)57-42-39(60-41-36(52)34(50)32(48)22(4)56-41)37(53)38(29(17-46)58-42)59-40-35(51)33(49)31(47)21(3)55-40/h7,19-22,24-42,46-53H,8-18H2,1-6H3/t19-,20+,21+,22+,24+,25-,26+,27+,28+,29-,30+,31+,32+,33-,34-,35-,36-,37+,38-,39-,40+,41+,42-,43+,44+,45-/m1/s1

InChI key

VNONINPVFQTJOC-ZGXDEBHDSA-N

说明

General description

薯蓣皂苷(Dioscin)是高度脂溶性的类固醇皂苷，存在于穿龙薯蓣(Dioscorea nipponica Makino)等多种薯蓣类植物中。

Application

薯蓣皂苷已用于研究其对缺血再灌注损伤(IRI)引起的神经损伤的抗炎和保护作用。还作为商业化皂苷用于比较分析并研究其在呼吸测量法中的细胞膜通透能力。

Biochem/physiol Actions

薯蓣皂苷(Dioscin)是强效的抗肿瘤试剂，对乳癌、肾癌、肺癌、肝癌、胃癌、急性髓系白血病等多种癌症具有强效抗癌作用。对肝、心、肾具有保护作用。还具有抗糖尿、抗真菌和抗病毒作用。

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存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

监管及禁止进口产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000493652

0000485599

0000484387

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HMGB-1/RAGE signaling inhibition by dioscin attenuates hippocampal neuron damage induced by oxygen-glucose deprivation/reperfusion.

Aijun Liu et al.

Experimental and therapeutic medicine, 20(6), 231-231 (2020-11-06)

Cerebral ischemia is one of the most common clinical diseases characterized by high morbidity and mortality. Neurocyte apoptosis and a cascade of inflammatory signals following cerebral ischemia-reperfusion injury (IRI) may contribute to secondary brain damage, resulting in severe neurological damage.

Dioscin: A diverse acting natural compound with therapeutic potential in metabolic diseases, cancer, inflammation and infections.

Xufeng Tao et al.

Pharmacological research, 137, 259-269 (2018-10-14)

Currently, the numbers of patients with cancer, fibrosis, diabetes, chronic kidney disease, stroke and osteoporosis are increasing fast and fast. It's critical necessary to discovery lead compounds for new drug development. Dioscin, one active compound in some medicinal plants, has

Comparative assessment of purified saponins as permeabilization agents during respirometry.

Corinna Dawid et al.

Biochimica et biophysica acta. Bioenergetics, 1861(10), 148251-148251 (2020-07-01)

Saponins are a diverse group of secondary plant metabolites, some of which display hemolytic toxicity due to plasma membrane permeabilization. This feature is employed in biological applications for transferring hydrophilic molecules through cell membranes. Widely used commercial saponins include digitonin

全球贸易项目编号

货号	GTIN
SMB00576-25MG	04061837076503

主要文件

薯蓣皂甙

≥95% (HPLC)

选择尺寸

关于此项目

Quality Level

assay

form

application(s)

storage temp.

SMILES string

InChI

InChI key

General description

Application

Biochem/physiol Actions

Still not finding the right product?

安全信息

存储类别

wgk

flash_point_f

flash_point_c

法规信息

文件

分析证书(COA)

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