SMB00915
BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester)
≥95% (HPLC)
别名:
BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester), (3α,5β,12β)-3,12-dihydroxy-11-oxo-cholan-24-oic-acid methyl ester
InChI
1S/C25H40O5/c1-14(5-10-20(27)30-4)18-8-9-19-17-7-6-15-13-16(26)11-12-24(15,2)21(17)22(28)23(29)25(18,19)3/h14-19,21,23,26,29H,5-13H2,1-4H3
InChI key
RYGJYUKSMUSEMY-UHFFFAOYSA-N
SMILES string
O=C(CCC(C1CCC2C3CCC4CC(CCC4(C3C(C(C12C)O)=O)C)O)C)OC
assay
≥95% (HPLC)
form
powder
color
white to beige
mp
153.5—154.5 °C
solubility
chloroform: 20 mg/mL, colorless to light yellow
storage temp.
2-8°C
Quality Level
相关类别
General description
BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) is a more potent analog of microbiome metabolite BAA485 (12-oxolithocholic acid) that activates the Pyrin inflammasome in myeloid and intestinal epithelial cells. BAA473 potently induces secretion of IL1β and IL18 in LPS-primed PBMCs and THP-1 cells.
Bile acids, natural steroid amphipathic compounds formed through cholesterol oxidation in the liver, play a crucial role in regulating lipid metabolism. They facilitate the digestion, absorption, and transport of lipids, lipid-soluble vitamins, and related molecules in the gastrointestinal tract. These bile acids also impact various aspects of cholesterol, glucose, and energy balance.
Application
BAA473 (11-oxo-12S-hydroxy lithocholic acid methyl ester) finds application in metabolomics, biochemical and microbiome research.
Features and Benefits
- Can be used in Metabolomics and Biochemical research
- High-quality compound suitable for multiple research applications
Other Notes
For additional information on our range of Biochemicals, please complete this form.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Irina Alimov et al.
The Journal of biological chemistry, 294(10), 3359-3366 (2019-01-17)
Bile acids are critical metabolites in the gastrointestinal tract and contribute to maintaining intestinal immune homeostasis through cross-talk with the gut microbiota. The conversion of bile acids by the gut microbiome is now recognized as a factor affecting both host
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