SMB01002
Guineensine
≥90% (LC/MS-ELSD)
别名:
(2E,4E,12E)-13-(1,3-benzodioxol-5-yl)-N-isobutyl-trideca-2,4,12-trienamide, Pipyahyine
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关于此项目
经验公式（希尔记法）:
C24H33NO3
化学文摘社编号:
分子量:
383.52
UNSPSC Code:
12352205
NACRES:
NA.25
MDL number:
SMILES string
N(CC(C)C)C(=O)\C=C\C=C\CCCCCC\C=C\c1cc2c(cc1)OCO2
InChI
1S/C24H33NO3/c1-20(2)18-25-24(26)14-12-10-8-6-4-3-5-7-9-11-13-21-15-16-22-23(17-21)28-19-27-22/h8,10-17,20H,3-7,9,18-19H2,1-2H3,(H,25,26)/b10-8+,13-11+,14-12+
InChI key
FPMPOFBEYSSYDQ-AUVZEZIHSA-N
biological source
plant
assay
≥90% (LC/MS-ELSD)
form
solid
mol wt
383.52
solubility
water: slightly soluble
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
General description
Guineensine, also known as Pipyahyine, is an alkaloid and a member of benzodioxoles is a natural product commonly available from Piper Sp.(P. nigrum and P. longum and P. retrofractum) plants. Existing research suggests that this plant-derived metabolite exerts various biological activities, including antimicrobial, anticancer, anti-inflammatory, antiviral and antioxidant properties.
Application
It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
Biochem/physiol Actions
According to the existing research, Guineensine inhibits endocannabinoid uptake, leading to significant anti-inflammatory and analgesic effects, and also interacts with various receptors, including dopamine transporter DAT, 5HT2A, and sigma receptors, suggesting potential polypharmacological activity.
Features and Benefits
- High quality compound suitable for multiple research applications
- Compatible with HPLC and mass spectrometry techniques
Other Notes
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Ruben Bartholomäus et al.
ChemMedChem, 14(17), 1590-1596 (2019-07-20)
Guineensine ((2E,4E,12E)-13-(benzo[d][1,3]dioxol-5-yl)-N-isobutyltrideca-2,4,12-trienamide) is a plant-derived natural product that inhibits reuptake of the endocannabinoid anandamide with sub-micromolar potency. We have established a highly efficient total synthesis of guineensine, which provided the natural product in only five steps from commercially available 3-nonyn-1-ol
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