SMB01019
Amorfrutin A
≥90% (LC/MS-ELSD)
别名:
2-hydroxy-4-methoxy-3-(3-methylbut-2-enyl)-6-(2-phenylethyl)benzoic acid, 3-hydroxy-4-isopentenyl-5-methoxybibenzyl-2-carboxylic acid
生物来源
plant
方案
≥90% (LC/MS-ELSD)
表单
solid
分子量
340.41
溶解性
water: slightly soluble
应用
metabolomics
vitamins, nutraceuticals, and natural products
储存温度
−20°C
SMILES字符串
O(C)c1c(c(c(c(c1)CCc2ccccc2)C(=O)O)O)CC=C(C)C
InChI
1S/C21H24O4/c1-14(2)9-12-17-18(25-3)13-16(19(20(17)22)21(23)24)11-10-15-7-5-4-6-8-15/h4-9,13,22H,10-12H2,1-3H3,(H,23,24)
InChI key
CTNFTPUIYFUXBE-UHFFFAOYSA-N
一般描述
Amorfrutin A is a stilbenoid compound commonly present in plants like Glycyrrhiza foetida, Glycyrrhiza acanthocarpa, Cajanus cajan, and Amorpha fruticosa. Current research indicates that this naturally occurring metabolite possesses diverse biological activities, including anti-inflammatory, anticancer, antidiabetic, and antimicrobial properties.
应用
It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
生化/生理作用
According to the existing research, Amorfrutin-A demonstrated its ability to inhibit NF-κB activity, a pivotal regulator of genes governing a wide range of cellular functions, such as immune responses, apoptosis, tumor growth, and tissue development. Furthermore, it exhibits anti-inflammatory properties in colon cells by interacting with the nuclear receptor PPARγ, resulting in the reduced expression and secretion of inflammatory mediators. This suggests its potential for treating conditions like inflammatory bowel diseases. Additionally, it also exhibited antidiabetic activity through binding to and activating the nuclear receptor PPARγ.
特点和优势
- High quality compound suitable for multiple research applications
- Compatible with HPLC and mass spectrometry techniques
其他说明
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储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
Amorfrutins are potent antidiabetic dietary natural products
Weidner C, et al.
Proceedings of the National Academy of Sciences of the USA, 109, 7257-7262 (2012)
Amorfrutins Are Natural PPAR? Agonists with Potent Anti-inflammatory Properties
Fuhr L, et al.
Journal of Natural Products, 78, 1160-1164 (2015)
Nguyen Tien Dat et al.
Journal of natural products, 71(10), 1696-1700 (2008-10-10)
NF-kappaB is known to play a crucial role in the regulation of genes controlling the immune system, apoptosis, tumor cell growth, and tissue differentiation. Bioassay-guided fractionation of the n-hexane-soluble fraction of a methanol extract of Amorpha fruticosa afforded four new
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