SMILES string
[o]1c2c([c](c(c1)c4cc(c(cc4)O)O)=O)c(c(c3c2C=CC(O3)(C)C)CC=C(C)C)O
InChI
1S/C25H24O6/c1-13(2)5-7-15-21(28)20-22(29)17(14-6-8-18(26)19(27)11-14)12-30-24(20)16-9-10-25(3,4)31-23(15)16/h5-6,8-12,26-28H,7H2,1-4H3
InChI key
GHCZYXUOYFOXIP-UHFFFAOYSA-N
biological source
plant
assay
≥90% (LC/MS-ELSD)
form
solid
mol wt
420.45
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
General description
Pomiferin is a prenylated flavonoid and a bioactive natural compound commonly derived from plants such as Citrus aurantium, Derris montana, Maclura pomifera, and Acacia horrida. Current research indicates that this metabolite is an inhibitor and may possess diverse biological activities, including antimicrobial, anticancer, antioxidant, anti-inflammatory, and neuroprotective properties.
Application
Pomiferin is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
Biochem/physiol Actions
Pomiferin acts as an potential inhibitor of HDAC, with an IC50 of 1.05 μM, and also potently inhibits mTOR (IC50, 6.2 μM). Pomiferin shows cytotoxic effects on human tumor cell lines. Pomiferin also increases SOD activities and total antioxidative capacity, and decreases malondialdehyde in rats.
Features and Benefits
- Suitable for Biochemical and Biomedical research
- Versatile and adaptable for wide variety of laboratory and research applications
Other Notes
For additional information on our range of Biochemicals, please complete this form.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Il Hong Son et al.
Bioorganic & medicinal chemistry letters, 17(17), 4753-4755 (2007-07-31)
The major constituents from the fruits of Maclura pomifera are the prenylated isoflavones, osajin (1) and pomiferin (2). Their structures were elucidated using NMR spectroscopic techniques and mass spectrometric analysis. Compound 2 showed potential inhibitory activity in histone deacetylase (HDAC)
Raymond Yang et al.
Journal of agricultural and food chemistry, 59(24), 13328-13336 (2011-11-18)
Pomiferin and osajin are prenylated isoflavones from Osage orange fruit that both have potent antioxidant activity in a variety of assays. Pomiferin, in particular, has strong activity against the superoxide anion in a photochemiluminescence (PCL) assay system. In vitro, pomiferin
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