SMB01065
Neolicuroside
≥85% (LC/MS-ELSD)
别名:
4-O-(beta-D-apiofuranosyl(1-2)-beta-D-glucopyranosyl)isoliquiritigenin, Isoliquiritigenin-4′-O-apiosyl(1→2)glucoside, Isoliquiritin apioside
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关于此项目
经验公式（希尔记法）:
C26H30O13
化学文摘社编号:
分子量:
550.51
UNSPSC Code:
12352205
NACRES:
NA.25
MDL number:
SMILES string
O1[C@H]([C@@H]([C@@](C1)(O)CO)O)O[C@H]2[C@@H](O[C@@H]([C@H]([C@@H]2O)O)CO)Oc3ccc(cc3)\C=C\C(=O)c4c(cc(cc4)O)O
InChI
1S/C26H30O13/c27-10-19-20(32)21(33)22(39-25-23(34)26(35,11-28)12-36-25)24(38-19)37-15-5-1-13(2-6-15)3-8-17(30)16-7-4-14(29)9-18(16)31/h1-9,19-25,27-29,31-35H,10-12H2/b8-3+/t19-,20-,21+,22-,23+,24-,25+,26-/m1/s1
InChI key
VMMVZVPAYFZNBM-KVFWHIKKSA-N
biological source
plant
assay
≥85% (LC/MS-ELSD)
form
solid
mol wt
550.51
solubility
water: slightly soluble
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
General description
Natural product derived from plant source.
Neolicuroside, also known as Isoliquiritin apioside, is a chalcone glycoside structurally related to steroidal saponins. This bioactive plant metabolite is commonly derived from the roots of Glycyrrhiza Sp. plants and has demonstrated anti-inflammatory, anti-tussive, anti-tumor, antigenotoxic(1), anti-diabetic, and antioxidant properties.
Application
It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
Biochem/physiol Actions
Neolicuroside modulates signaling pathways (e.g., MAPK, NF-κB), impacting vital cell processes such as proliferation, differentiation, and apoptosis. Its multitargeted mechanism includes scavenging free radicals, suppressing pro-inflammatory cytokine production, inhibiting matrix metalloproteinase (MMP) activity and hindering cancer cell growth through apoptosis and cell cycle arrest. Furthermore, it also exerts immunomodulatory effects possibly by activating toll-like receptor 4 (TLR4).
Features and Benefits
- High quality compound suitable for multiple research applications
- Compatible with HPLC and mass spectrometry techniques
Other Notes
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Evaluation of antigenotoxic activity of isoliquiritin apioside from Glycyrrhiza glabra L
Kaur P, et al.
Toxicology in vitro, 23, 680-686 (2009)
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