SMB01077
Poliothyrsoside
≥85% (LC/MS-ELSD)
别名:
Nigracin
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关于此项目
经验公式（希尔记法）:
C20H22O9
化学文摘社编号:
分子量:
406.38
UNSPSC Code:
12352205
NACRES:
NA.25
MDL number:
SMILES string
O1[C@H]([C@@H]([C@H]([C@@H]([C@H]1COC(=O)c3ccccc3)O)O)O)Oc2c(cc(cc2)O)CO
InChI
1S/C20H22O9/c21-9-12-8-13(22)6-7-14(12)28-20-18(25)17(24)16(23)15(29-20)10-27-19(26)11-4-2-1-3-5-11/h1-8,15-18,20-25H,9-10H2/t15-,16-,17+,18-,20-/m1/s1
InChI key
FLROYCKIIJCTDY-BFMVXSJESA-N
biological source
plant
assay
≥85% (LC/MS-ELSD)
form
solid
mol wt
406.38
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
General description
Poliothyrsoside, also known as Nigracin, is a phenolic glycoside compound commonly found in plants such as Flacourtia indica, Loxocalyx urticifolius, Hydnocarpus annamensis, Xylosma flexuosa, Poliothyrsis sinensis, and Scolopia spinosa. Existing research suggests that this plant-derived metabolite exerts various biological activities, antioxidant, antidiabetic, anti-alzheimers and antiplasmodial properties.
Application
It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical and biochemical research.
Biochem/physiol Actions
Poliothyrsoside is a pyruvic transaminase inhibitor known for its insulin-sensitizing effects in cell culture. Additionally, it exhibits anti-diabetic properties by inhibiting acetyl-CoA carboxylase, ultimately enhancing insulin sensitivity and lowering blood glucose levels in diabetic mice. This compound also serves as a lactate dehydrogenase inhibitor and demonstrates antidepressant-like actions, along with effectiveness against Alzheimer′s disease. In vitro studies have further revealed Poliothyrsoside′s capacity to inhibit virus production and exhibit antiviral activity against HIV-1.
Features and Benefits
- High quality compound suitable for multiple research applications
- Compatible with HPLC and mass spectrometry techniques
Other Notes
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Gianluca Sferrazza et al.
Frontiers in pharmacology, 10, 1541-1541 (2020-02-11)
Drypetes klainei Pierre ex Pax is used in Cameroon by Baka people in the wound healing process and for the treatment of burns. In a previous paper we demonstrated the ability of both water (WE) and defatted methanol (DME) extracts
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