SMB01078
Inulicin
≥90% (LC/MS-ELSD)
别名:
1-O-Acetylbritannilactone, Britannilactone 1-O-acetate
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关于此项目
经验公式（希尔记法）:
C17H24O5
化学文摘社编号:
分子量:
308.37
UNSPSC Code:
12352205
NACRES:
NA.25
MDL number:
SMILES string
O1[C@H]2[C@H]([C@@H](C(=C(C2)C)[C@H](CCCOC(=O)C)C)O)C(=C)C1=O
InChI
1S/C17H24O5/c1-9(6-5-7-21-12(4)18)14-10(2)8-13-15(16(14)19)11(3)17(20)22-13/h9,13,15-16,19H,3,5-8H2,1-2,4H3/t9-,13+,15+,16+/m0/s1
InChI key
QKUFZFLZBUSEHN-CZLJMHDISA-N
biological source
plant
assay
≥90% (LC/MS-ELSD)
form
solid
mol wt
308.37
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
General description
Inulicin, a sesquiterpene lactone, is a natural bioactive compound commonly sourced from plants like Pentanema britannicum and Inula japonica. Current research indicates that this plant-derived metabolite may possess inhibitory properties, showcasing a range of biological activities, including anti-inflammatory, cardioprotective, antiangiogenic, and anticancer activities.
Application
Inulicin is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
Biochem/physiol Actions
Inulicin exhibits anticancer properties by inhibiting angiogenesis and lung cancer cell proliferation, potentially through the regulation of VEGFR-Src-FAK signaling. When combined with gemcitabine, it promotes strong apoptosis in lung cancer cells. Additionally, Inulicin shows promise in the treatment of various cardiovascular diseases, including chronic ischemia, by modulating VEGF signaling and angiogenesis. It also serves as a potent inhibitor of LPS-induced inflammatory responses in vascular smooth muscle cells, acting through the blockade of NF-kappaB activity and the suppression of the inflammatory gene COX-2. Furthermore, Inulicin displays potential as a natural skin-lightening agent, reducing melanogenesis by suppressing tyrosinase expression via ERK and Akt signaling pathways.
Features and Benefits
- Suitable for Biochemical and Biomedical research
- Versatile and adaptable for wide variety of laboratory and research applications
Other Notes
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
L F Belova et al.
Farmakologiia i toksikologiia, 44(4), 463-467 (1981-07-01)
Inulicin is a sesquiterpene lactone obtained from Inula Japonica L. (Compositae) possesses a fairly wide spectrum of pharmacological action. In doses from 5 to 60 mg/kg it exerts a certain stimulant action on the central nervous system and smooth muscles
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