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关于此项目
经验公式(希尔记法):
C20H26N2O4 ·HCl
化学文摘社编号:
分子量:
394.89
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
伊托必利 盐酸盐, ≥98% (HPLC)
SMILES string
Cl.COc1ccc(cc1OC)C(=O)NCc2ccc(OCCN(C)C)cc2
InChI key
ZTOUXLLIPWWHSR-UHFFFAOYSA-N
InChI
1S/C20H26N2O4.ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4;/h5-10,13H,11-12,14H2,1-4H3,(H,21,23);1H
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
H2O: ≥48 mg/mL
originator
Abbott
storage temp.
2-8°C
Quality Level
相关类别
signalword
Warning
hcodes
pcodes
Hazard Classifications
Aquatic Acute 1 - Aquatic Chronic 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Sanjay Bansal et al.
Drug delivery, 23(2), 437-451 (2014-05-29)
The objectives of present studies were to develop the systematically optimized multiple-unit gastroretentive microballoons, i.e. hollow microspheres of itopride hydrochloride (ITH) employing quality by design (QbD)-based approach. Initially, the patient-centric QTPP and CQAs were earmarked, and preliminary studies were conducted
[Effect of HSR-803 on gastrointestinal motility].
H Iwanaga et al.
Nihon Heikatsukin Gakkai zasshi, 25(6), 313-315 (1989-12-01)
N Kishibayashi et al.
Japanese journal of pharmacology, 66(4), 397-403 (1994-12-01)
KW-5092 ([1-[2-[[[5-(piperidinomethyl)-2- furanyl]methyl]amino]ethyl]-2-imidazolidinylidene] propanedinitrile fumarate) is a novel gastroprokinetic agent with acetylcholinesterase (AChE) inhibitory activity and acetylcholine release facilitatory activity. The present study used guinea pig ileal homogenates to examine the inhibitory effects of KW-5092 on the activities of AChE
E Takahara et al.
Journal of chromatography, 576(1), 174-178 (1992-04-15)
A method based on high-performance liquid chromatography using column-switching is described for the simultaneous determination of HSR-803 and its metabolites in human serum and urine. The system uses a six-port valve with a Nucleosil CN pre-column for on-line sample clean-up
Y Iwanaga et al.
Gastroenterology, 99(2), 401-408 (1990-08-01)
A novel water-soluble dopamine-2 antagonist, N-[4-[2-(dimethylamino) ethoxy]benzyl]-3,4-dimethoxybenzamide hydrochloride (HSR-803) was synthesized and assayed for its gastrointestinal smooth muscle stimulating activity in vivo and in vitro. In the in vivo study, gastrointestinal contractile activity was measured by means of chronically implanted
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