SML0038
Fluvastatin 钠 水合物
≥98% (HPLC), HMG-CoA reductase inhibitor, powder
别名:
(±)-(3R*,5S*,6E)-7-[3-(4-氟苯基)-1-(1-甲基乙基)-1H-吲哚-2-基]-3,5-二羟基-6-辛酸钠盐水合物
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C24H25FNO4 · Na · xH2O
化学文摘社编号:
分子量:
433.45 (anhydrous basis)
UNSPSC Code:
12352204
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Fluvastatin 钠 水合物, ≥98% (HPLC)
SMILES string
O.[Na+].CC(C)n1c(\C=C\[C@@H](O)C[C@@H](O)CC([O-])=O)c(-c2ccc(F)cc2)c3ccccc13
InChI
1S/C24H26FNO4.Na.H2O/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);;1H2/q;+1;/p-1/b12-11+;;/t18-,19-;;/m1../s1
InChI key
KKEMYLLTGGQWCE-PMRANXHDSA-M
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
H2O: ≥9 mg/mL
originator
Novartis
storage temp.
2-8°C
Quality Level
Application
氟伐地汀钠水合物已被用于：
- 测试其抗丙肝病毒 (HCV) 活性
- 作为胆固醇抑制剂
- 研究其对β-葡聚糖诱导的单核细胞免疫驯化的作用
氟伐地汀钠水合物已被用于：
- 考察其对β -葡聚糖诱导的免疫驯化的作用
- 研究斯达汀对解偶联蛋白 (UCP1)+细胞数目的影响
- 确定其对星形胶质细胞胰岛素降解酶 (IDE) 分泌的影响
- 治疗并研究其对脐静脉内皮细胞 (HUVEC) 的体外作用
Biochem/physiol Actions
氟伐他汀是羟甲基戊二酰辅酶A（HMG-CoA）还原酶的一种竞争性抑制剂，该酶可催化HMG-CoA转化为甲羟戊酸，而这是胆固醇生物合成中的限速步骤。氟伐他汀可抗血脂，能用于降低血浆胆固醇的水平并预防心血管疾病。
氟伐地汀具有抗真菌活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Kazuho Sakamoto et al.
The Journal of pharmacology and experimental therapeutics, 338(1), 62-69 (2011-04-07)
HMG-CoA reductase inhibitor statins are used for the treatment of hypercholesterolemia. However, statins have adverse effects on skeletal muscles with unknown mechanism. We have reported previously that fluvastatin induced vacuolation and cell death in rat skeletal myofibers by depleting geranylgeranylpyrophosphate
Avasimibe: a novel hepatitis C virus inhibitor that targets the assembly of infectious viral particles
Hu L, et al.
Antiviral Research, 148, 5-14 (2017)
Statins induce insulin-degrading enzyme secretion from astrocytes via an autophagy-based unconventional secretory pathway
Son SM, et al.
Mol. Neurodegener., 10(1), 56-56 (2015)
Inhibition of mevalonate pathway prevents adipocyte browning in mice and men by affecting protein prenylation
Balaz M, et al.
Cell Metabolism, 29(4), 901-916 (2019)
Mojca Lunder et al.
Atherosclerosis, 215(2), 446-451 (2011-02-09)
Early arterial wall changes are already present in the apparently healthy, middle-aged population and continuously progress with age. The aim of our study was to investigate whether 30 days low-dose fluvastatin treatment could improve and reverse these arterial changes that
商品
Discover Bioactive Small Molecules for Lipid Signaling Research
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持