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经验公式(希尔记法):
C15H15NO2S
化学文摘社编号:
分子量:
273.35
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1
SMILES string
NC(=O)CS(=O)C(c1ccccc1)c2ccccc2
InChI key
YFGHCGITMMYXAQ-LJQANCHMSA-N
assay
≥98% (HPLC)
form
powder
optical activity
[α]/D -15 to -20° in methanol (C=1)
color
white to tan
solubility
DMSO: ≥16 mg/mL
originator
Teva
storage temp.
2-8°C
Quality Level
Gene Information
human ... SLC6A3(6531)
Application
阿莫达非尼可用于细胞信号传导研究。
Biochem/physiol Actions
阿莫达非尼对多巴胺转运蛋白具有亲和力,并抑制参与认知功能的脑区对多巴胺的摄取。对物质滥用和精神障碍患者有益。
阿莫达非尼是一种精神兴奋促醒剂。
阿莫达非尼是外消旋莫达非尼的 R 异构体和更持久的异构体。它是一种精神兴奋促醒剂,开发用于治疗与阻塞性睡眠呼吸暂停相关的发作性睡病、轮班工作睡眠障碍和白天过度嗜睡
阿莫非尼是一种非苯丙胺药物,半衰期为10−14 小时。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Armodafinil and modafinil have substantially different pharmacokinetic profiles despite having the same terminal half-lives
Darwish M, et al.
Clinical Drug Investigation, 29(9), 613-623 (2009)
Marianna Harvanová et al.
Journal of pharmaceutical and biomedical analysis, 138, 267-271 (2017-02-24)
For the first time, a new, fast and sensitive chromatographic method for the separation and determination of modafinil enantiomers was developed on chiral stationary phase with macrocyclic glycopeptide teicoplanin in the polar organic mode. The effect of the mobile phase
Adjunct armodafinil improves wakefulness and memory in obstructive sleep apnea/hypopnea syndrome
Hirshkowitz M, et al.
Respiratory Medicine, 101(3), 616-627 (2007)
Maddalena Mereu et al.
Psychopharmacology, 229(3), 415-434 (2013-08-13)
Modafinil (MOD) and its R-enantiomer (R-MOD) are approved medications for narcolepsy and other sleep disorders. They have also been used, off-label, as cognitive enhancers in populations of patients with mental disorders, including substance abusers that demonstrate impaired cognitive function. A
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