SML0039
莫达非尼
≥98% (HPLC)
别名:
(R)-莫达非尼；2-[(R)-（二苯基甲基）亚磺酰基]-乙酰胺，CEP 10952，CRL 40982，Nuvigil
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关于此项目
经验公式（希尔记法）:
C15H15NO2S
化学文摘社编号:
分子量:
273.35
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
旋光性
[α]/D -15 to -20° in methanol (C=1)
颜色
white to tan
溶解性
DMSO: ≥16 mg/mL
创始人
Teva
储存温度
2-8°C
SMILES字符串
NC(=O)CS(=O)C(c1ccccc1)c2ccccc2
InChI
1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)/t19-/m1/s1
InChI key
YFGHCGITMMYXAQ-LJQANCHMSA-N
基因信息
human ... SLC6A3(6531)
警示用语：
Warning
危险声明
危险分类
Acute Tox. 4 Oral - Repr. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Marianna Harvanová et al.
Journal of pharmaceutical and biomedical analysis, 138, 267-271 (2017-02-24)
For the first time, a new, fast and sensitive chromatographic method for the separation and determination of modafinil enantiomers was developed on chiral stationary phase with macrocyclic glycopeptide teicoplanin in the polar organic mode. The effect of the mobile phase
Armodafinil and modafinil have substantially different pharmacokinetic profiles despite having the same terminal half-lives
Darwish M, et al.
Clinical Drug Investigation, 29(9), 613-623 (2009)
Adjunct armodafinil improves wakefulness and memory in obstructive sleep apnea/hypopnea syndrome
Hirshkowitz M, et al.
Respiratory Medicine, 101(3), 616-627 (2007)
Maddalena Mereu et al.
Psychopharmacology, 229(3), 415-434 (2013-08-13)
Modafinil (MOD) and its R-enantiomer (R-MOD) are approved medications for narcolepsy and other sleep disorders. They have also been used, off-label, as cognitive enhancers in populations of patients with mental disorders, including substance abusers that demonstrate impaired cognitive function. A
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