主要文件

查看所有文档

SML0041

巴马司他

Name: 巴马司他
Brand: SIGMA

≥98% (HPLC), powder, matrix metalloproteinase inhibitor

别名:

BB-94；（2R,3S）-N4- 羟基-N1-[（1S）-2-（甲基氨基）-2-氧代-1-（苯甲基）乙基] -2-（2-甲基丙基）-3-[（2-噻吩基硫基基）甲基] 丁二酰胺

登录查看组织和合同定价。

选择尺寸

变更视图

关于此项目

经验公式（希尔记法）:

C₂₃H₃₁N₃O₄S₂

化学文摘社编号:

130370-60-4

分子量:

477.64

UNSPSC Code:

12352200

PubChem Substance ID:

329825111

NACRES:

NA.77

MDL number:

MFCD00866533

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

技术服务

需要帮助？我们经验丰富的科学家团队随时乐意为您服务。

让我们为您提供帮助

产品名称

巴马司他, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥15 mg/mL

shipped in

wet ice

storage temp.

−20°C

SMILES string

CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(C)C)[C@H](CSc2cccs2)C(=O)NO

InChI

1S/C23H31N3O4S2/c1-15(2)12-17(18(22(28)26-30)14-32-20-10-7-11-31-20)21(27)25-19(23(29)24-3)13-16-8-5-4-6-9-16/h4-11,15,17-19,30H,12-14H2,1-3H3,(H,24,29)(H,25,27)(H,26,28)/t17-,18+,19+/m1/s1

InChI key

XFILPEOLDIKJHX-QYZOEREBSA-N

正在寻找类似产品? 访问产品对比指南

Application

巴马司他已在多种研究中被用于抑制基质金属蛋白酶（MMP）的活性。

Biochem/physiol Actions

巴马司他是一种有效的广谱基质金属蛋白酶（MMP）抑制剂。

巴马司他是基质金属蛋白酶（MMP）的异羟肟酸类抑制剂。它抑制小鼠模型中肺肿瘤的生长和扩散，乳腺癌再生和人结肠肿瘤的生长和扩散。巴马司他降低 MMP 介导的血管功能障碍和血管壁损伤，并增强牙科粘合剂的密封性能和粘合强度。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000438276

0000344612

0000344613

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

S100A4 elevation empowers expression of metastasis effector molecules in human breast cancer

Ismail TM, et al.

Cancer Research, 77(3), 780-789 (2017)

Matrix metalloproteinase inhibition delays wound healing and blocks the latent transforming growth factor-beta1-promoted myofibroblast formation and function.

Ursula Mirastschijski et al.

Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 18(2), 223-234 (2010-04-23)

The ability to regulate wound contraction is critical for wound healing as well as for pathological contractures. Matrix metalloproteinases (MMPs) have been demonstrated to be obligatory for normal wound healing. This study examined the effect that the broad-spectrum MMP inhibitor

Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease.

Joseph D Raffetto et al.

Biochemical pharmacology, 75(2), 346-359 (2007-08-07)

Matrix metalloproteinases (MMPs) are a family of proteolytic enzymes that degrade various components of the extracellular matrix (ECM). Members of the MMP family include collagenases, gelatinases, stromelysins, matrilysins and membrane-type MMPs. ProMMPs are cleaved into active forms that promote degradation

Matrix metalloproteinase inhibitor BB-94 (batimastat) inhibits human colon tumor growth and spread in a patient-like orthotopic model in nude mice.

X Wang et al.

Cancer research, 54(17), 4726-4728 (1994-09-01)

Matrix metalloproteinases have been implicated in the growth and spread of metastatic tumors. This role was investigated in an orthotopic transplant model of human colon cancer in nude mice using the matrix metalloproteinase inhibitor BB-94 (batimastat). Fragments of human colon

Inhibition of Pseudomonas aeruginosa secreted virulence factors reduces lung inflammation in CF mice

Sandri A, et al.

Virulence, 9(1), 1008-1018 (2018)

查看所有相关文献

全球贸易项目编号

货号	GTIN
SML0041-25MG	04061833221617
SML0041-5MG	04061837076640

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持