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Merck
CN

SML0044

Sigma-Aldrich

Tubastatin A 盐酸盐

≥98% (HPLC), Selective HDAC6 inhibitor, powder

别名:

N-羟基-4-(2-甲基-1,2,3,4-四氢-吡啶并[4,3-b]吲哚-5-基甲基)苯甲酰胺盐酸盐；N-羟基-4-((2-甲基-3,4-二氢-1H-吡啶并[4,3-b]吲哚-5(2H)- 基)甲基)苯甲酰胺 盐酸盐

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关于此项目

经验公式（希尔记法）:
C20H21N3O2·HCl
化学文摘社编号:
1310693-92-5
分子量:
371.86
MDL编号:
MFCD20488052
UNSPSC代码:
12352200
PubChem化学物质编号:
329825114
NACRES:
NA.77

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产品名称

Tubastatin A 盐酸盐, ≥98% (HPLC)

质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to tan

溶解性

DMSO: ≥10 mg/mL

运输

wet ice

储存温度

−20°C

SMILES字符串

O=C(NO)C1=CC=C(CN2C3=C(C=CC=C3)C4=C2CCN(C)C4)C=C1.Cl

InChI

1S/C20H21N3O2.ClH/c1-22-11-10-19-17(13-22)16-4-2-3-5-18(16)23(19)12-14-6-8-15(9-7-14)20(24)21-25;/h2-9,25H,10-13H2,1H3,(H,21,24);1H

InChI key

LJTSJTWIMOGKRJ-UHFFFAOYSA-N

相关类别

应用

Tubastatin A盐酸盐可用于HDAC6介导的细胞信号传导研究。

生化/生理作用

Tubastatin A是一种选择性很强的HDAC6抑制剂，IC50为4 nM，它对HDAC6的选择性比其他HDAC类高100至1000倍以上。
Tubastatin A盐酸盐是一种选择性很强的HDAC6抑制剂。
Tubastatin A能够增加线粒体的总数并恢复DRG神经元中移动线粒体的数量。它能够逆转腓骨肌萎缩症小鼠模型中外周神经元的轴突丧失。 Tubastatin A可以抑制小鼠成肌细胞中α-微管蛋白的去乙酰化。

特点和优势

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000427105
0000427104
0000427104
0000427105
0000358626

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