SML0059
BLT-1
≥98% (HPLC)
别名:
2-己基-1-环戊酮氨基硫脲, 33M20, BLT1, MIT 9952-53, 阻断脂质转运-1
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关于此项目
经验公式（希尔记法）:
C12H23N3S
CAS Number:
分子量:
241.40
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to tan
溶解性
DMSO: ≥13 mg/mL
储存温度
2-8°C
SMILES字符串
CCCCCCC1CCC\C1=N/NC(N)=S
InChI
1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+
InChI key
OWGUSBISUVLUJF-SDNWHVSQSA-N
应用
BLT-1可用于研究在胆固醇流入和流出中起作用的细胞信号通路。
BLT-1（阻断脂质转运-1）已被用作SR-BI（清道夫受体，B类，I型）介导的脂质转移的抑制剂，以确定miR-223-3p是否从多形核中性粒细胞（PMN）输出高密度脂蛋白（HDL）依赖于SR-BI介导的脂质通量。它也被用作SR-BI抑制剂，通过SR-B1研究HDL对单核细胞系中骨钙素（OCN）表达的影响。
生化/生理作用
SR-BI（清道夫受体，B类，I型）介导的脂质转移的特异性抑制剂
阻断脂质转运-1（BLT-1）是SR-BI（清道夫受体，B类，I型）介导的脂质转移的特异性抑制剂。该化合物抑制HDL胆固醇醚的细胞选择性脂质摄取和细胞胆固醇向HDL的流出。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
High density lipoprotein modulates osteocalcin expression in circulating monocytes: a potential protective mechanism for cardiovascular disease in type 1 diabetes
Maddaloni E, et al.
Cardiovascular Diabetology, 16(1), 1-11 (2017)
Ivana Halova et al.
Frontiers in immunology, 3, 119-119 (2012-06-02)
Migration of mast cells is essential for their recruitment within target tissues where they play an important role in innate and adaptive immune responses. These processes rely on the ability of mast cells to recognize appropriate chemotactic stimuli and react
Ceren Emre et al.
Brain pathology (Zurich, Switzerland), 30(3), 614-640 (2020-01-09)
Neuroinflammation is a key element of AD pathology and conceivably a result of a disturbed resolution. Resolution of inflammation is an active process which is strictly orchestrated following the acute inflammatory response after removal of the inflammatory stimuli. Acute inflammation
Fumiyuki Sasaki et al.
PloS one, 12(9), e0185133-e0185133 (2017-09-19)
Leukotriene B4 (LTB4) receptor 1 (BLT1) is a G protein-coupled receptor expressed in various leukocyte subsets; however, the precise expression of mouse BLT1 (mBLT1) has not been reported because a mBLT1 monoclonal antibody (mAb) has not been available. In this
Christine Bassila et al.
Journal of lipid research, 65(5), 100541-100541 (2024-04-08)
HDLs carry sphingosine-1-phosphate (S1P) and stimulate signaling pathways in different cells including macrophages and endothelial cells, involved in atherosclerotic plaque development. HDL signaling via S1P relies on the HDL receptor scavenger receptor class B, type I (SR-B1) and the sphingosine-1-phosphate
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