SML0059
BLT-1
≥98% (HPLC)
别名:
2-己基-1-环戊酮氨基硫脲, 33M20, BLT1, MIT 9952-53, 阻断脂质转运-1
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C12H23N3S
化学文摘社编号:
分子量:
241.40
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
产品名称
BLT-1, ≥98% (HPLC)
InChI
1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+
SMILES string
CCCCCCC1CCC\C1=N/NC(N)=S
InChI key
OWGUSBISUVLUJF-SDNWHVSQSA-N
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥13 mg/mL
storage temp.
2-8°C
Quality Level
Application
BLT-1可用于研究在胆固醇流入和流出中起作用的细胞信号通路。
BLT-1（阻断脂质转运-1）已被用作SR-BI（清道夫受体，B类，I型）介导的脂质转移的抑制剂，以确定miR-223-3p是否从多形核中性粒细胞（PMN）输出高密度脂蛋白（HDL）依赖于SR-BI介导的脂质通量。它也被用作SR-BI抑制剂，通过SR-B1研究HDL对单核细胞系中骨钙素（OCN）表达的影响。
Biochem/physiol Actions
SR-BI（清道夫受体，B类，I型）介导的脂质转移的特异性抑制剂
阻断脂质转运-1（BLT-1）是SR-BI（清道夫受体，B类，I型）介导的脂质转移的特异性抑制剂。该化合物抑制HDL胆固醇醚的细胞选择性脂质摄取和细胞胆固醇向HDL的流出。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Fumiyuki Sasaki et al.
PloS one, 12(9), e0185133-e0185133 (2017-09-19)
Leukotriene B4 (LTB4) receptor 1 (BLT1) is a G protein-coupled receptor expressed in various leukocyte subsets; however, the precise expression of mouse BLT1 (mBLT1) has not been reported because a mBLT1 monoclonal antibody (mAb) has not been available. In this
Christine Bassila et al.
Journal of lipid research, 65(5), 100541-100541 (2024-04-08)
HDLs carry sphingosine-1-phosphate (S1P) and stimulate signaling pathways in different cells including macrophages and endothelial cells, involved in atherosclerotic plaque development. HDL signaling via S1P relies on the HDL receptor scavenger receptor class B, type I (SR-B1) and the sphingosine-1-phosphate
Yue-Hua Feng et al.
Lipids in health and disease, 17(1), 200-200 (2018-08-27)
Scavenger receptor BI (SR-BI) is a classic high-density lipoprotein (HDL) receptor, which mediates selective lipid uptake from HDL cholesterol esters (HDL-C). Apolipoprotein M (ApoM), as a component of HDL particles, could influence preβ-HDL formation and cholesterol efflux. The aim of
Ceren Emre et al.
Brain pathology (Zurich, Switzerland), 30(3), 614-640 (2020-01-09)
Neuroinflammation is a key element of AD pathology and conceivably a result of a disturbed resolution. Resolution of inflammation is an active process which is strictly orchestrated following the acute inflammatory response after removal of the inflammatory stimuli. Acute inflammation
Ivana Halova et al.
Frontiers in immunology, 3, 119-119 (2012-06-02)
Migration of mast cells is essential for their recruitment within target tissues where they play an important role in innate and adaptive immune responses. These processes rely on the ability of mast cells to recognize appropriate chemotactic stimuli and react
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持