跳转至内容
Merck
CN

SML0065

Tubacin

≥98% (HPLC), histone deacetylase 6 (HDAC6) inhibitor, powder

别名:

N1-[4-[(2R,4R,6S)-4-[[（4,5-二苯基-2-恶唑基）硫代] 甲基]-6-[4-（羟甲基）苯基]-1,3-二恶烷-2-基] 苯基]-N8-羟基-辛二酰胺

登录 查看组织和合同定价。

选择尺寸

关于此项目

经验公式（希尔记法）:
C41H43N3O7S
化学文摘社编号:
537049-40-4
分子量:
721.86
UNSPSC Code:
12352200
PubChem Substance ID:
329825129
NACRES:
NA.77
MDL number:
MFCD18452824

主要文件

查看所有文档
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助
技术服务
需要帮助？我们经验丰富的科学家团队随时乐意为您服务。
让我们为您提供帮助

产品名称

Tubacin, ≥98% (HPLC)

SMILES string

OCC1=CC=C(C=C1)[C@@H]2C[C@H](CSC3=NC(C4=CC=CC=C4)=C(C5=CC=CC=C5)O3)O[C@H](C6=CC=C(NC(CCCCCCC(NO)=O)=O)C=C6)O2

InChI

1S/C41H43N3O7S/c45-26-28-17-19-29(20-18-28)35-25-34(27-52-41-43-38(30-11-5-3-6-12-30)39(51-41)31-13-7-4-8-14-31)49-40(50-35)32-21-23-33(24-22-32)42-36(46)15-9-1-2-10-16-37(47)44-48/h3-8,11-14,17-24,34-35,40,45,48H,1-2,9-10,15-16,25-27H2,(H,42,46)(H,44,47)/t34-,35+,40+/m1/s1

InChI key

BHUZLJOUHMBZQY-YXQOSMAKSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to tan

solubility

DMSO: ≥10 mg/mL

shipped in

wet ice

storage temp.

−20°C

Quality Level

100

相关类别

Application

Tubacin被用于研究 HDAC6 在膀胱癌细胞迁移和侵袭中的作用。

Biochem/physiol Actions

Tubacin 可触发活性氧的释放并介导不依赖 caspase-3 的 eb 病毒 (EBV) 阳性 Burkitt 淋巴瘤细胞凋亡。它可抑制急性淋巴细胞白血病 (ALL) 细胞的增殖，增强ALL细胞化疗效果。Tubacin 可预防大鼠中由于 Srpx2 表达降低引起的癫痫活动和神经元迁移缺陷。
Tubacin 是组蛋白去乙酰化酶 6 (HDAC6) 的选择性抑制剂，HDAC6 是一种主要参与许多细胞过程的细胞质 II 类组蛋白去乙酰化酶，包括错误折叠蛋白的降解、细胞迁移和细胞间相互作用。Tubacin 选择性抑制 HDAC6 介导的 α-微管蛋白去乙酰化。
选择性组蛋白去乙酰化酶 6 (HDAC6) 抑制剂

Features and Benefits

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000335086
0000335086
0000156780
0000156781
0000156780

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Manal Salmi et al.
Brain : a journal of neurology, 136(Pt 8), 2457-2473 (2013-07-09)
Altered development of the human cerebral cortex can cause severe malformations with often intractable focal epileptic seizures and may participate in common pathologies, notably epilepsy. This raises important conceptual and therapeutic issues. Two missense mutations in the sushi repeat-containing protein
Junichi Kawada et al.
The Journal of biological chemistry, 284(25), 17102-17109 (2009-04-24)
Tubacin is a small molecule inhibitor of histone deacetylase 6 and blocks aggresome activity. We found that Epstein-Barr virus (EBV)-positive Burkitt lymphoma (BL) cells were generally killed by lower doses of tubacin than EBV-transformed lymphoblastoid cells (LCLs) or EBV-negative BL
Harald Witte et al.
The Journal of cell biology, 180(3), 619-632 (2008-02-13)
Axon formation is the initial step in establishing neuronal polarity. We examine here the role of microtubule dynamics in neuronal polarization using hippocampal neurons in culture. We see increased microtubule stability along the shaft in a single neurite before axon
Qinqin Zuo et al.
Oncology reports, 27(3), 819-824 (2011-11-18)
Histone deacetylase 6 (HDAC6) promotes cell motility and contributes to the metastasis of cancers. The purpose of this study was to investigate the role of HDAC6 in human bladder cancer for the first time. The results showed that HDAC6 promotes
Laura Melchionda et al.
Orphanet journal of rare diseases, 8, 66-66 (2013-05-03)
We studied a family including two half-siblings, sharing the same mother, affected by slowly progressive, adult-onset neurological syndromes. In spite of the diversity of the clinical features, characterized by a mild movement disorder with cognitive impairment in the elder patient
查看所有相关文献

商品

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系客户支持