SML0066
NGB 2904 hydrochloride
≥98% (HPLC)
别名:
N-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl]butyl]-9H-fluorene-2-carboxamide hydrochloride
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关于此项目
经验公式（希尔记法）:
C28H29Cl2N3O·HCl
化学文摘社编号:
分子量:
530.92
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
PFIWYJNBKGCVFM-UHFFFAOYSA-N
SMILES string
Cl.Clc1cccc(N2CCN(CCCCNC(=O)c3ccc-4c(Cc5ccccc-45)c3)CC2)c1Cl
InChI
1S/C28H29Cl2N3O.ClH/c29-25-8-5-9-26(27(25)30)33-16-14-32(15-17-33)13-4-3-12-31-28(34)21-10-11-24-22(19-21)18-20-6-1-2-7-23(20)24;/h1-2,5-11,19H,3-4,12-18H2,(H,31,34);1H
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
DMSO: ≥25 mg/mL
storage temp.
2-8°C
Quality Level
Application
NGB 2904 hydrochloride may be used in cell signaling studies.
Biochem/physiol Actions
Inhibition of dopamine D3 receptor function by NGB 2904 increases spontaneous locomotor activity in rodents.
NGB 2904 hydrochloride is a potent and selective dopamine D3 receptor antagonist
NGB 2904 is a potent and selective dopamine D3 receptor antagonist with a D3/D2 ratio of 800 for rat and high binding affinity (1.4 nM) at the hD3 receptor with 150-fold selectivity for primate D3 receptors over primate D2L receptors. It attenuates the rewarding effects of cocaine and methamphetamine.
Features and Benefits
This compound is featured on the Dopamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Laurel M Pritchard et al.
Pharmacology, biochemistry, and behavior, 86(4), 718-726 (2007-04-06)
The dopamine D3 receptor is believed to play an important role in regulation of rodent locomotor behavior, and has been proposed as a therapeutic target for substance abuse, psychotic disorders, and Parkinson's disease. One model of dopamine D3 receptor function
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