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SML0068

CTP Inhibitor

Name: CTP Inhibitor
Brand: SIGMA

≥98% (HPLC), mitochondrial citrate transport protein inhibitor, powder

别名:

ZINC Compound 792949; 4-Chloro-3-[[(3-nitrophenyl)amino]sulfonyl]-benzoic acid

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关于此项目

经验公式（希尔记法）:

C₁₃H₉ClN₂O₆S

化学文摘社编号:

412940-35-3

分子量:

356.74

UNSPSC Code:

12352200

PubChem Substance ID:

329825132

NACRES:

NA.77

MDL number:

MFCD01122300

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

产品名称

CTP Inhibitor, ≥98% (HPLC)

Quality Level

100

assay

≥98% (HPLC)

form

powder

color

white to tan

solubility

DMSO: ≥23 mg/mL

storage temp.

2-8°C

SMILES string

OC(=O)c1ccc(Cl)c(c1)S(=O)(=O)Nc2cccc(c2)[N+]([O-])=O

InChI

1S/C13H9ClN2O6S/c14-11-5-4-8(13(17)18)6-12(11)23(21,22)15-9-2-1-3-10(7-9)16(19)20/h1-7,15H,(H,17,18)

InChI key

IIJQJWNGBILZCU-UHFFFAOYSA-N

说明

Application

CTP inhibitor may be used in cell signaling studies.
CTP inhibitor has been used in mouse to study the transition of endothelial to mesenchymal cells.

Biochem/physiol Actions

CTP Inhibitor is an inhibitor of mitochondrial citrate transport protein, was the first purely competitive inhibitor to be discovered and is more potent than BTC.

CTP inhibitor blocks the exchange of tricarboxylates the key intermediates in anabolism and catabolism by mitochondrial citrate transport protein (CTP).

存储类别

11 - Combustible Solids

wgk

WGK 3

历史批次信息供参考:

分析证书(COA)

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Succinyl-CoA Ligase Deficiency in Pro-inflammatory and Tissue-Invasive T Cells.

Bowen Wu et al.

Cell metabolism, 32(6), 967-980 (2020-12-03)

Autoimmune T cells in rheumatoid arthritis (RA) have a defect in mitochondrial oxygen consumption and ATP production. Here, we identified suppression of the GDP-forming β subunit of succinate-CoA ligase (SUCLG2) as an underlying abnormality. SUCLG2-deficient T cells reverted the tricarboxylic acid (TCA)

Spatio-temporal dynamics of replication and transcription sites in the mammalian cell nucleus.

Kishore S Malyavantham et al.

Chromosoma, 117(6), 553-567 (2008-07-05)

To study when and where active genes replicated in early S phase are transcribed, a series of pulse-chase experiments are performed to label replicating chromatin domains (RS) in early S phase and subsequently transcription sites (TS) after chase periods of

A metabolic basis for endothelial-to-mesenchymal transition

Xiong J, et al.

Molecular Cell, 69, 689-698 (2018)

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全球贸易项目编号

货号	GTIN
SML0068-25MG	04061833221662
SML0068-5MG	04061833221679