SML0070
Salsalate
≥98% (HPLC), COX inhibitor, powder
别名:
2-(2-Hydroxybenzoyl)oxybenzoic acid, 2-Hydroxybenzoic acid 2-carboxyphenyl ester, disalicylic acid, salicyloxysalicylic acid, salicylsalicylic acid
产品名称
Salsalate, ≥98% (HPLC)
方案
≥98% (HPLC)
表单
powder
颜色
white to tan
溶解性
DMSO: ≥15 mg/mL
储存温度
room temp
SMILES字符串
OC(=O)c1ccccc1OC(=O)c2ccccc2O
InChI
1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)
InChI key
WVYADZUPLLSGPU-UHFFFAOYSA-N
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应用
Salsalate was used to study the effect on palmitate-induced insulin resistance and hepatic steatosis in obese rats.
生化/生理作用
NSAID; Nonacetylated aspirin analog
Salsalate is a nonsteroidal anti-inflammatory drug (NSAID), a nonacetylated salicylate with no more problems of gastrointestinal bleeding than placebo. It inhibits synthesis and release of prostaglandins through the inactivation of cyclooxygenase-1 (COX-1) and COX-2. Salsalate is currently being investigated as a treatment for Type 2 diabetes with possible use to prevent the disease in people at risk. It reduces blood glucose concentrations in patients with type 2 diabetes, as well as in insulin-resistant patients without diabetes.
警示用语：
Warning
危险分类
Acute Tox. 4 Oral - Aquatic Chronic 3 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2
储存分类代码
11 - Combustible Solids
WGK
WGK 2
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
此项目有
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kristen L Jablonski et al.
Hypertension (Dallas, Tex. : 1979), 57(1), 63-69 (2010-12-01)
We tested the hypothesis that vascular endothelial function, assessed by endothelium-dependent dilation, is related to serum vitamin D status among middle-aged and older adults without clinical disease, and that this is linked to inflammation. Brachial artery flow-mediated dilation, a measure
Tae Woo Jung et al.
PloS one, 8(6), e66529-e66529 (2013-07-05)
Selenoprotein P (SeP) was recently identified as a hepatokine that induces insulin resistance (IR) in rodents and humans. Recent clinical trials have shown that salsalate, a prodrug of salicylate, significantly lowers blood glucose levels and increases adiponectin concentrations. We examined
J Koska et al.
Diabetologia, 52(3), 385-393 (2008-12-24)
Low-grade inflammation may contribute to obesity-related insulin resistance and has been associated with increased risk of type 2 diabetes mellitus. The present study evaluated whether treatment with salsalate, a traditional anti-inflammatory medication, would improve insulin action in obese non-diabetic individuals.
Roberta Noberini et al.
Chemical biology & drug design, 78(4), 667-678 (2011-07-28)
Eph receptor tyrosine kinases and ephrin ligands control many physiological and pathological processes, and molecules interfering with their interaction are useful probes to elucidate their complex biological functions. Moreover, targeting Eph receptors might enable new strategies to inhibit cancer progression
Tae Woo Jung et al.
Biochemical pharmacology, 86(7), 960-969 (2013-08-21)
Fetuin-A was recently identified as a novel hepatokine which is associated with obesity, insulin resistance and non-alcoholic fatty liver disease. Salsalate, a prodrug of salicylate with an anti-inflammatory effect and lower side effect profile, significantly lowers glucose and triglyceride levels
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