Salsalate

Name: Salsalate
Brand: SIGMA

≥98% (HPLC)

别名:

2-(2-Hydroxybenzoyl)oxybenzoic acid, 2-Hydroxybenzoic acid 2-carboxyphenyl ester, disalicylic acid, salicyloxysalicylic acid, salicylsalicylic acid

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所有图片(1)

About This Item

经验公式（希尔记法）:

C₁₄H₁₀O₅

CAS Number:

552-94-3

分子量:

258.23

EC 号:

209-027-4

MDL编号:

MFCD00020252

UNSPSC代码:

12352200

PubChem化学物质编号:

329825134

NACRES:

NA.77

质量水平

100

方案

≥98% (HPLC)

表单

powder

颜色

white to tan

溶解性

DMSO: ≥15 mg/mL

储存温度

room temp

SMILES字符串

OC(=O)c1ccccc1OC(=O)c2ccccc2O

InChI

1S/C14H10O5/c15-11-7-3-1-5-9(11)14(18)19-12-8-4-2-6-10(12)13(16)17/h1-8,15H,(H,16,17)

InChI key

WVYADZUPLLSGPU-UHFFFAOYSA-N

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应用

Salsalate was used to study the effect on palmitate-induced insulin resistance and hepatic steatosis in obese rats.

生化/生理作用

NSAID; Nonacetylated aspirin analog

Salsalate is a nonsteroidal anti-inflammatory drug (NSAID), a nonacetylated salicylate with no more problems of gastrointestinal bleeding than placebo. It inhibits synthesis and release of prostaglandins through the inactivation of cyclooxygenase-1 (COX-1) and COX-2. Salsalate is currently being investigated as a treatment for Type 2 diabetes with possible use to prevent the disease in people at risk. It reduces blood glucose concentrations in patients with type 2 diabetes, as well as in insulin-resistant patients without diabetes.