SML0076
Zoniporide hydrochloride hydrate
≥98% (HPLC), sodium-hydrogen exchanger isoform 1 (NHE-1) inhibitor, powder
别名:
N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate
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关于此项目
经验公式（希尔记法）:
C17H16N6O · xHCl · yH2O
化学文摘社编号:
分子量:
320.35 (anhydrous free base basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated
产品名称
Zoniporide hydrochloride hydrate, ≥98% (HPLC)
Quality Segment
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
H2O: 2 mg/mL, clear (warmed)
storage temp.
2-8°C
SMILES string
O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4
InChI
1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2
InChI key
UCIJUEGJEFJRMP-UHFFFAOYSA-N
Application
Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.
Zoniporide hydrochloride hydrate may be used in Na+/H+-mediated cell signaling studies.
Biochem/physiol Actions
Potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1)
Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.
Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults. It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats. Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable