SML0076
Zoniporide hydrochloride hydrate
≥98% (HPLC)
别名:
N-(Aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide hydrochloride hydrate
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About This Item
经验公式（希尔记法）:
C17H16N6O · xHCl · yH2O
CAS Number:
分子量:
320.35 (anhydrous free base basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white to tan
溶解性
H2O: 2 mg/mL, clear (warmed)
储存温度
2-8°C
SMILES字符串
O.Cl.NC(=N)NC(=O)c1cnn(-c2cccc3ncccc23)c1C4CC4
InChI
1S/C17H16N6O.ClH.H2O/c18-17(19)22-16(24)12-9-21-23(15(12)10-6-7-10)14-5-1-4-13-11(14)3-2-8-20-13;;/h1-5,8-10H,6-7H2,(H4,18,19,22,24);1H;1H2
InChI key
UCIJUEGJEFJRMP-UHFFFAOYSA-N
相关类别
应用
Zoniporide hydrochloride hydrate has been used for the inhibition of sodium-hydrogen exchanger isoform 1 (NHE-1) in rat models. It has also been used in cytotoxicity assay and to study its effect on lymphocytic choriomeningitis virus multiplication.
Zoniporide hydrochloride hydrate may be used in Na+/H+-mediated cell signaling studies.
生化/生理作用
Potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1)
Zoniporide is a potent and selective inhibitor of Na+/H+ exchanger isoform 1 (NHE-1). IC50 = 59 nM at NHE-1, vs. 12,000 nM at NHE-2; Zoniporide inhibits NHE-1-dependent Na+ update with IC50 of 14 nM.
Zoniporide, a selective inhibitor of sodium-hydrogen exchanger isoform 1 (NHE-1) has cardioprotective effects against myocardial injuries and ischemic insults. It inhibits the swelling human platelets and attenuates cardiac contractile dysfunction in rats. Zoniporide might have neurotoxic effects as it causes peripheral sensory axonopathy.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
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