SML0077
VU591
≥98% (HPLC)
别名:
2,2′-(oxydimethanediyl)bis(5-nitro-1H-benzimidazole), 2,2′-(oxydimethanediyl)bis(6-nitro-1H-benzimidazole), 5-nitro-2-{[(6-nitro-1H-benzimidazol-2-yl)methoxy]methyl}-1H-benzimidazole
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关于此项目
经验公式（希尔记法）:
C16H12N6O5
化学文摘社编号:
分子量:
368.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
VU591, ≥98% (HPLC)
SMILES string
[O-][N+](=O)c1ccc2nc(COCc3nc4ccc(cc4[nH]3)[N+]([O-])=O)[nH]c2c1
InChI
1S/C16H12N6O5/c23-21(24)9-1-3-11-13(5-9)19-15(17-11)7-27-8-16-18-12-4-2-10(22(25)26)6-14(12)20-16/h1-6H,7-8H2,(H,17,19)(H,18,20)
InChI key
ZQPXNYLXYNRFNP-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥12 mg/mL
storage temp.
2-8°C
Quality Level
Gene Information
human ... KCNJ1(3758)
Application
VU591 may be used in cell signaling studies.
Biochem/physiol Actions
ROMK (Kir 1.1) inhibitor
VU591 is a Potassium Inwardly-Rectifying Channel (KCNJ1 or ROMK) specific inhibitor (IC50 = 240 nM) that is closely related to VU590. Unlike VU590, VU591 does not inhibit Kir7.1. The compound has a modest effect on Kir6.2/SUR1, causing 17% inhibition at 10 uM.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Guglielmo Schiano et al.
Scientific reports, 9(1), 19517-19517 (2019-12-22)
Uromodulin, the most abundant protein in normal urine, is produced by cells lining the thick ascending limb (TAL) of the loop of Henle. Uromodulin regulates the activity of the potassium channel ROMK in TAL cells. Common variants in KCNJ1, the
Jiun-Lin Horng et al.
Scientific reports, 7(1), 16215-16215 (2017-11-28)
Molecular mechanisms of Na
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