SML0095
Conessine
≥97% (HPLC)
别名:
(3β)-N,N-dimethyl-con-5-enin-3-amine, Conessin, NSC 119994, Neriine, Roquessine, Wrightine
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关于此项目
经验公式（希尔记法）:
C24H40N2
化学文摘社编号:
分子量:
356.59
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-897-2
MDL number:
InChI key
GPLGAQQQNWMVMM-MYAJQUOBSA-N
InChI
1S/C24H40N2/c1-16-20-8-9-22-19-7-6-17-14-18(25(3)4)10-12-23(17,2)21(19)11-13-24(20,22)15-26(16)5/h6,16,18-22H,7-15H2,1-5H3/t16-,18-,19+,20+,21-,22-,23-,24-/m0/s1
SMILES string
C[C@H]1[C@H]2CC[C@H]3[C@@H]4CC=C5C[C@H](CC[C@]5(C)[C@H]4CC[C@]23CN1C)N(C)C
assay
≥97% (HPLC)
form
powder
color
white to tan
solubility
ethanol: ≥2 mg/mL
originator
Abbott
storage temp.
2-8°C
Quality Level
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General description
Conessine is a steroidal alkaloid. It has anti-malarial properties, thus, conessine has been used in treatment of malaria.
Biochem/physiol Actions
Conessine is a plant steroid alkaloid that acts as a potent and specific antagonist of histamine H3 receptors (Ki = 5.37 and 24.5 nM for human and rat receptors, respectively). Conessine is 1860-fold selective for H3 over H4 and does not bind to H1 or H2 receptors. The molecule also binds to the human α2C4 adrenergic receptor (pKi = 7.98).
H3 receptor antagonist
Features and Benefits
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
[Dibromhydr Amino-oxyconessine dibromhydrate in the treatment of intestinal or hepatic amebiasis; results].
R CROSNIER et al.
Bulletin de la Societe de pathologie exotique et de ses filiales, 45(1), 86-92 (1952-01-01)
[Emetine resistant amebiasis, a major indication for conessine].
J VAGUE
Archives des maladies de l'appareil digestif et des maladies de la nutrition, 40(6), 808-810 (1951-06-01)
[Considerations of the slowness of urinary elimination of conessine].
J P PLUCHON et al.
Annales pharmaceutiques francaises, 8(11), 741-744 (1950-11-01)
Aman D Kaur et al.
Journal of pharmaceutical and biomedical analysis, 46(2), 391-394 (2007-11-17)
A new, simple, sensitive, precise and robust high-performance thin layer chromatographic (HPTLC) method was developed for the estimation of conessine in herbal extracts and pharmaceutical dosage forms. Analysis of conessine was performed on TLC aluminium plates pre-coated with silica gel
[Experimental studies of conessine. Cultures of dysenteric amoeba in mediums to which chlorhydrates of conessine or emetine were previously added].
M PIETTE
Annales pharmaceutiques francaises, 8(5), 410-414 (1950-05-01)
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