SML0097
奈韦拉平
≥98% (HPLC), HIV-1 reverse transcriptase inhibitor, powder
别名:
11-环丙基-5,11-二氢-4-甲基-6H-二吡啶基[3,2-b:2′,3′-e][1,4] 二氮杂- 6-酮
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关于此项目
经验公式（希尔记法）:
C15H14N4O
化学文摘社编号:
分子量:
266.30
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
产品名称
奈韦拉平,
assay
≥98% (HPLC)
Quality Segment
form
powder
color
white to tan
solubility
DMSO: ≥22 mg/mL
storage temp.
room temp
SMILES string
CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O
InChI
1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)
InChI key
NQDJXKOVJZTUJA-UHFFFAOYSA-N
Application
Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication, primary hepatocytes and bone marrow dendritic cells (BMDCs).
Biochem/physiol Actions
Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase. It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome.
HIV-1 的 NNRTI（非核苷类逆转录酶抑制剂）
奈韦拉平是 HIV 逆转录酶（NNRTI）的变构非核苷抑制剂。奈韦拉平抑制野生型 RT 的 Ki 为 200 nM。
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存储类别
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable