Name: 奈韦拉平
Brand: SIGMA

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About This Item

经验公式（希尔记法）:

C₁₅H₁₄N₄O

CAS Number:

129618-40-2

分子量:

266.30

MDL编号:

MFCD00866928

UNSPSC代码:

12352200

PubChem化学物质编号:

329825155

NACRES:

NA.77

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方案

≥98% (HPLC)

表单

powder

颜色

white to tan

溶解性

DMSO: ≥22 mg/mL

储存温度

room temp

SMILES字符串

CC1=CC=NC2=C1NC(C(C=CC=N3)=C3N2C4CC4)=O

InChI

1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)

InChI key

NQDJXKOVJZTUJA-UHFFFAOYSA-N

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应用

Nevirapine has been used as non-nucleoside reverse transcriptase inhibitor in in vitro porcine endogenous retrovirus replication, primary hepatocytes and bone marrow dendritic cells (BMDCs).

生化/生理作用

HIV-1 的 NNRTI（非核苷类逆转录酶抑制剂）

奈韦拉平是 HIV 逆转录酶（NNRTI）的变构非核苷抑制剂。奈韦拉平抑制野生型 RT 的 K_i 为 200 nM。

Nevirapine interacts with glycine 190 residue of human immuno deficiency virus (HIV-2) reverse transcriptase. It is an antiretroviral drug which increases bile synthesis and activates electron transport chain. Use of nevirapine leads to liver toxicity and is associated with Nevirapine hypersensitivity syndrome.