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SML0099

醋酸肤轻松

Name: 醋酸肤轻松
Brand: SIGMA

≥98% (HPLC)

别名:

(6α,11β,16α)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione, Lonide

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关于此项目

经验公式（希尔记法）:

C₂₆H₃₂F₂O₇

化学文摘社编号:

356-12-7

分子量:

494.52

NACRES:

NA.77

PubChem Substance ID:

329825157

UNSPSC Code:

51111800

EC Number:

206-597-6

MDL number:

MFCD00079302

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

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属性

Quality Level

100

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +75 to +90°, c = 1 in dichloromethane

color

white to tan

solubility

DMSO: ≥19 mg/mL

storage temp.

2-8°C

SMILES string

CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]23C

InChI

1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1

InChI key

WJOHZNCJWYWUJD-IUGZLZTKSA-N

Gene Information

human ... NR3C1(2908)

说明

Biochem/physiol Actions

Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.

Fluocinonide has been used to study its effect on T-cell proliferation.

Fluocinonide is shown to be effective in the treatment of atopic dermatitis and oral lichen planus (OLP).

very potent corticosteroid

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signalword

Danger

Hazard Classifications

Acute Tox. 2 Oral - Repr. 2

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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Topical application of drugs used in treatment of oral lichen planus lesions.

Małgorzata Radwan-Oczko

Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 22(6), 893-898 (2014-01-17)

Oral lichen planus is a common, chronic mucosal disease associated with a cell-mediated immunological dysfunction. The clinical manifestation is different when various forms, white and red, are considered. Erosive, atrophic, ulcerative lesions require long-term treatment, because of inflammation and severe

Adherence to a five day treatment course of topical fluocinonide 0.1% cream in atopic dermatitis.

Emily Hix et al.

Dermatology online journal, 19(10), 20029-20029 (2013-10-22)

Adherence in the treatment of chronic inflammatory skin diseases such as atopic dermatitis is poor. Methods to improve adherence have proven difficult. To determine whether a short course of treatment with a high-potency corticosteroid will improve adherence compared to longer

Topical application of a corticosteroid destabilizes the host-parasite relationship in an experimental model of the oral carrier state of Candida albicans.

N Deslauriers et al.

FEMS immunology and medical microbiology, 11(1), 45-55 (1995-03-01)

Using an experimental model in the mouse we have shown that both local and central lines of defense, involving CD4+ T cells, participate in a dynamic interaction to maintain a long-term carrier state of Candida albicans in the oral cavity.

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全球贸易项目编号

货号	GTIN
SML0099-50MG	04061833221778
SML0099-10MG	04061833221761

主要文件

醋酸肤轻松

≥98% (HPLC)

选择尺寸

关于此项目

Quality Level

assay

form

optical activity

color

solubility

storage temp.

SMILES string

InChI

InChI key

Gene Information

Biochem/physiol Actions

Still not finding the right product?

安全信息

signalword

pictograms

hcodes

pcodes

Hazard Classifications

存储类别

wgk

flash_point_f

flash_point_c

法规信息

文件

分析证书(COA)

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全球贸易项目编号