Merck
CN
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文件

安全信息

SML0099

Sigma-Aldrich

醋酸肤轻松

≥98% (HPLC)

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别名:
(6α,11β,16α)-21-(acetyloxy)-6,9-difluoro-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-pregna-1,4-diene-3,20-dione, Lonide
经验公式（希尔记法）:
C26H32F2O7
CAS号:
356-12-7
分子量:
494.52
EC 号:
206-597-6
MDL编号:
MFCD00079302
PubChem化学物质编号:
329825157
NACRES:
NA.77

质量水平

100

检测方案

≥98% (HPLC)

形式

powder

旋光性

[α]/D +75 to +90°, c = 1 in dichloromethane

颜色

white to tan

溶解性

DMSO: ≥19 mg/mL

储存温度

2-8°C

SMILES字符串

CC(=O)OCC(=O)[C@@]12OC(C)(C)O[C@@H]1C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@]23C

InChI

1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1

InChI key

WJOHZNCJWYWUJD-IUGZLZTKSA-N

基因信息

human ... NR3C1(2908)

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生化/生理作用

Flucinonide is a fluorinated glucocorticid that is used as a topical anti-inflammatory agent. Recently, flucinonide and other fluorinated glucocorticolids were identified as smoothend agonists. Flucinonide induces expression of Gli-reporter luciferase in Shh-LIGHT2 cells.
Fluocinonide has been used to study its effect on T-cell proliferation.
Fluocinonide is shown to be effective in the treatment of atopic dermatitis and oral lichen planus (OLP).

象形图

Skull and crossbonesHealth hazard
GHS06,GHS08

警示用语：

Danger

危险声明

H300 - H361

危险分类

Acute Tox. 2 Oral - Repr. 2

储存分类代码

6.1A - Combustible, acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

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Małgorzata Radwan-Oczko
Advances in clinical and experimental medicine : official organ Wroclaw Medical University, 22(6), 893-898 (2014-01-17)
Oral lichen planus is a common, chronic mucosal disease associated with a cell-mediated immunological dysfunction. The clinical manifestation is different when various forms, white and red, are considered. Erosive, atrophic, ulcerative lesions require long-term treatment, because of inflammation and severe
Emily Hix et al.
Dermatology online journal, 19(10), 20029-20029 (2013-10-22)
Adherence in the treatment of chronic inflammatory skin diseases such as atopic dermatitis is poor. Methods to improve adherence have proven difficult. To determine whether a short course of treatment with a high-potency corticosteroid will improve adherence compared to longer
N Deslauriers et al.
FEMS immunology and medical microbiology, 11(1), 45-55 (1995-03-01)
Using an experimental model in the mouse we have shown that both local and central lines of defense, involving CD4+ T cells, participate in a dynamic interaction to maintain a long-term carrier state of Candida albicans in the oral cavity.
Localized acral pityriasis lichenoides chronica: report of a case.
Jennifer J Halbesleben et al.
The Journal of dermatology, 38(8), 832-834 (2011-03-01)
Ginette A Hinds et al.
Dermatology online journal, 14(11), 11-11 (2008-12-20)
Disseminate and recurrent infundibulofolliculitis (DRIF) is an uncommon pruritic follicular eruption of unknown etiology that is predominantly seen in black men. This condition tends to affect the trunk and upper extremities and is usually unresponsive to local and systemic treatment.
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