SML0103
AMTB 水合物
≥98% (HPLC)
别名:
N-（3-氨基丙基）-2-[（3-甲基苯基）甲氧基]-N-（2-噻吩基甲基）-苯甲酰胺盐酸盐（1:1） 单盐酸半乙醇半水合物
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选择尺寸
关于此项目
经验公式（希尔记法）:
C23H26N2O2S·HCl · xH2O
化学文摘社编号:
分子量:
430.99 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
AMTB 水合物, ≥98% (HPLC)
SMILES string
O=C(C1=C(OCC2=C(C)C=CC=C2)C=CC=C1)N(CCCN)CC3=CC=CS3.Cl.O
InChI
1S/C23H26N2O2S.ClH.H2O/c1-18-8-2-3-9-19(18)17-27-22-12-5-4-11-21(22)23(26)25(14-7-13-24)16-20-10-6-15-28-20;;/h2-6,8-12,15H,7,13-14,16-17,24H2,1H3;1H;1H2
InChI key
RTYVTAQFASBIDN-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to tan
solubility
DMSO: ≥10 mg/mL
storage temp.
2-8°C
Quality Level
Application
AMTB水合物已被用作瞬时受体电位通道、melastatin亚家族、乳腺癌细胞成员8（TRPM8） 和鼠T 细胞的抑制剂。
Biochem/physiol Actions
AMTB 是一种 2-苄氧基苯甲酸酰胺衍生物， 它可抑制电压门控钠通道（Nav）及其同工型。
AMTB是TRPM8离子通道阻滞剂
AMTB是一种TRPM8选择性拮抗剂，与TRPV1或4没有交叉反应性。 icilin激活TRPM8的pIC50为6.23静脉注射给药AMTB，可以减少容量负荷膀胱的节律性收缩频率，并抑制血压和对膀胱扩张的内脏运动反射反应。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Átila Pereira-Gonçalves et al.
Pflugers Archiv : European journal of physiology, 470(12), 1803-1813 (2018-09-13)
1,8-Cineole is a cyclic monoterpenoid used in folk medicine for treatment of numerous respiratory diseases and other infections. 1,8-Cineole has anti-inflammatory, antioxidant, and myorelaxant effects, as well as low toxicity. In the present study, the effects of 1,8-cineole on contractility
Yutong Sui et al.
Fitoterapia, 145, 104631-104631 (2020-05-23)
Transient receptor potential melastatin 8 (TRPM8) is a calcium ion-permeable cation channel that is used as a prognostic marker and therapeutic target for different tumor types. To identify natural selective TRPM8 antagonists, we tested 158 traditional Chinese medicine (TCM) compounds
Kunsala T D S Yapa et al.
Life sciences, 198, 128-135 (2018-03-03)
To assess levels of the calcium permeable transient receptor potential cation channel, subfamily melastatin, member 8 (TRPM8) in breast cancer molecular subtypes and to assess the consequences of TRPM8 pharmacological inhibition with AMTB (an inhibitor of TRPM8) on breast cancer
Tusar K Acharya et al.
Cell biology international, 45(1), 198-210 (2020-10-23)
The transient receptor potential melastatin 8 (TRPM8) is an ion channel that has been widely studied as a cold-sensitive nociceptor. However, its importance in nonneuronal cells is mostly unexplored. Here, we describe the presence and functional significance of endogenous TRPM8
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