SML0117
磷苯妥英 二钠盐 水合物
≥98% (HPLC)
别名:
5,5-Diphenyl-3-[(phosphonooxy)methyl]-2,4-imidazolidinedione disodium salt hydrate
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关于此项目
经验公式(希尔记法):
C16H13N2Na2O6P · xH2O
化学文摘社编号:
分子量:
406.24 (anhydrous basis)
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to tan
溶解性
H2O: ≥15 mg/mL
储存温度
2-8°C
SMILES字符串
O.[Na+].[Na+].[O-]P([O-])(=O)OCN1C(=O)NC(C1=O)(c2ccccc2)c3ccccc3
InChI
1S/C16H15N2O6P.2Na.H2O/c19-14-16(12-7-3-1-4-8-12,13-9-5-2-6-10-13)17-15(20)18(14)11-24-25(21,22)23;;;/h1-10H,11H2,(H,17,20)(H2,21,22,23);;;1H2/q;2*+1;/p-2
InChI key
WPAVXKKGWCHUAK-UHFFFAOYSA-L
生化/生理作用
Fosphenytoin is a water soluble phenytoin prodrug.
anticonvulsant
警示用语:
Danger
危险声明
危险分类
Acute Tox. 4 Oral - Carc. 1B - Repr. 1B
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
新产品
Advisers recommend improved labeling for phenytoin, fosphenytoin.
Kate Traynor
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 67(24), 2086-2086 (2010-12-01)
Case 3-2009: a 9-month-old boy with seizures.
Ajit Singh Kashyap et al.
The New England journal of medicine, 360(15), 1572-1572 (2009-04-10)
Effect of an educational initiative on physicians' use of weight-based fosphenytoin loading doses in the emergency department.
April D Miller et al.
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 67(1), 15-16 (2010-01-02)
Clinical pharmacology of parenteral use of antiepileptic drugs.
Meir Bialer
Epilepsia, 48 Suppl 8, 46-48 (2008-03-11)
Linda A Steinbaugh et al.
Epilepsy & behavior : E&B, 23(3), 280-284 (2012-02-22)
Continuous electroencephalography (cEEG) is increasingly used to detect both clinical and subclinical seizures in patients with traumatic brain injury (TBI) or subarachnoid hemorrhage (SAH). We assess whether EEG findings predict outcomes in TBI/SAH patients enrolled in a levetiracetam (LEV) vs.
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