SML0128

M30 dihydrochloride

Name: M30 dihydrochloride
Brand: SIGMA

≥98% (HPLC)

别名:

5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride, M-30 dihydrochloride, VAR10300 dihydrochloride

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关于此项目

经验公式（希尔记法）:

C₁₄H₁₄N₂O · 2HCl

化学文摘社编号:

64821-19-8

分子量:

299.20

MDL编号:

MFCD20488063

UNSPSC代码:

12352200

PubChem化学物质编号:

329825178

NACRES:

NA.77

主要文件

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质量水平

100

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

green-yellow

溶解性

DMSO, heptane and xylene: ≥21 mg/mL

储存温度

2-8°C

SMILES字符串

Cl.Cl.CN(CC#C)Cc1ccc(O)c2ncccc12

InChI

1S/C14H14N2O.2ClH/c1-3-9-16(2)10-11-6-7-13(17)14-12(11)5-4-8-15-14;;/h1,4-8,17H,9-10H2,2H3;2*1H

InChI key

XJNICPXVRPOSSO-UHFFFAOYSA-N

应用

M30 dihydrochloride may be used in monamine oxidase-mediated cell signaling studies.

生化/生理作用

M30 is a site-activated iron chelator and monoamine oxidase (MAO) inhibitor; with neuroprotective and anti-apoptotic activity. It is a multifunctional non-toxic, brain permeable iron chelator possessing a neuroprotective propargylamine moiety and an antioxidant-iron chelator moiety. M30 is a selective irreversible inhibitor of mitochondrial brain monoamine oxidases A and B (MAO-A and -B), providing for improved levels of neurotransmitters. It reduces oxidative damage and shows neuroprotective and neurorestorative effects in various neurodegenerative models of ALS, Alzheimer′s and Parkinson′s diseases, and is being investigated in other diseases where oxidative stress is a problem.

Site-activated iron chelator and monoamine oxidase (MAO) inhibitor; neuroprotective and anti-apoptotic

特点和优势

This compound is featured on the Dopamine and Norepinephrine Metabolism and Histamine Synthesis and Metabolism pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.