SML0133
醋酸诺美孕酮
≥98% (HPLC)
别名:
17-Acetoxy-6-methyl-19-norpregna-4,6-diene-3,20-dione, NOMAc, Org 10486-0
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关于此项目
经验公式（希尔记法）:
C23H30O4
化学文摘社编号:
分子量:
370.48
UNSPSC Code:
51111800
PubChem Substance ID:
EC Number:
261-379-8
MDL number:
InChI key
IIVBFTNIGYRNQY-YQLZSBIMSA-N
InChI
1S/C23H30O4/c1-13-11-20-18(17-6-5-16(26)12-19(13)17)7-9-22(4)21(20)8-10-23(22,14(2)24)27-15(3)25/h11-12,17-18,20-21H,5-10H2,1-4H3/t17-,18-,20-,21+,22+,23+/m1/s1
SMILES string
CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)C(C)=O
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥7 mg/mL
storage temp.
2-8°C
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Biochem/physiol Actions
Nomegestrol acetate (NOMAc) is a potent, highly selective progestogen, a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors. It shows potent antigonadotropic activity mediated at the hypothalamic and pituitary level with strong antiestrogenic effects and a partial antiandrogenic effect. NOMAc is used in various formulations as a contraceptive.
Progestogen, contraceptive
signalword
Warning
hcodes
Hazard Classifications
Aquatic Acute 1 - Repr. 2
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
涉药品监管产品
此项目有
Romuald Debski et al.
Ginekologia polska, 83(4), 316-318 (2012-06-21)
Nomegestrol acetate (NOMAC) combined with E2 (Zoely) is a monophasic oral contraceptive (OC) which safety and efficacy was confirmed in a number of level I evidence clinical trials. Zoely is highly effective OC, especially in overweight and obese patients, with
Diana Mansour et al.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 16(6), 430-443 (2011-10-15)
The primary objective was to assess the efficacy, cycle control and tolerability of a monophasic combined oral contraceptive (COC) containing nomegestrol acetate (NOMAC) and 17β-oestradiol (E2). Effects on acne were evaluated as a secondary objective. Results were compared to those
Pasquale Florio et al.
Steroids, 75(12), 912-917 (2010-06-23)
The presence of a thin endometrium has an important role in allowing the best conditions for hysteroscopic surgery. Here, we explored the efficacy of a 14-day administration of nomegestrol acetate, a progestogen with high progestogen potency effects, in rapid endometrial
Ulla M Ågren et al.
The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception, 16(6), 458-467 (2011-09-29)
To compare the effects of two monophasic combined oral contraceptives, containing either nomegestrol acetate/17β-oestradiol (NOMAC/E2) or levonorgestrel/ ethinylestradiol (LNG/EE) on endocrine function, androgens, and sex hormone-binding globulin (SHBG). Randomised, open-label, multi-centre trial involving 121 healthy women, aged 18-50 years old.
Lily P H Yang et al.
Drugs, 72(14), 1917-1928 (2012-09-07)
Nomegestrol acetate/estradiol is a combined oral contraceptive with approval in many countries. This fixed-dose combination tablet contains nomegestrol acetate, a highly selective progestogen, and estradiol, a natural estrogen. It is the first monophasic combined oral contraceptive to contain estradiol, and
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