SML0133
醋酸诺美孕酮
≥98% (HPLC)
别名:
17-Acetoxy-6-methyl-19-norpregna-4,6-diene-3,20-dione, NOMAc, Org 10486-0
方案
≥98% (HPLC)
表单
powder
颜色
white to tan
溶解性
DMSO: ≥7 mg/mL
储存温度
2-8°C
SMILES字符串
CC(=O)O[C@@]1(CC[C@H]2[C@@H]3C=C(C)C4=CC(=O)CC[C@@H]4[C@H]3CC[C@]12C)C(C)=O
InChI
1S/C23H30O4/c1-13-11-20-18(17-6-5-16(26)12-19(13)17)7-9-22(4)21(20)8-10-23(22,14(2)24)27-15(3)25/h11-12,17-18,20-21H,5-10H2,1-4H3/t17-,18-,20-,21+,22+,23+/m1/s1
InChI key
IIVBFTNIGYRNQY-YQLZSBIMSA-N
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生化/生理作用
Nomegestrol acetate (NOMAc) is a potent, highly selective progestogen, a full agonist at the progesterone receptor, with no or minimal binding to other steroid receptors. It shows potent antigonadotropic activity mediated at the hypothalamic and pituitary level with strong antiestrogenic effects and a partial antiandrogenic effect. NOMAc is used in various formulations as a contraceptive.
Progestogen, contraceptive
警示用语：
Warning
危险声明
危险分类
Aquatic Acute 1 - Repr. 2
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
涉药品监管产品
此项目有
S Christin-Maitre et al.
Human reproduction (Oxford, England), 26(6), 1338-1347 (2011-03-23)
BACKGROUND Nomegestrol acetate/17β-estradiol (NOMAC/E(2)) is a new monophasic oral contraceptive combining NOMAC (2.5 mg), a highly selective progesterone-derived progestogen, with E(2) (1.5 mg), which is structurally identical to endogenous estrogen. The objective of this study was to compare the effects
Xiangyan Ruan et al.
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 28(11), 863-866 (2012-04-13)
Recently the first monophasic contraceptive pill containing estradiol has been developed which is thought to be a milestone in contraception. Nomegestrol acetate (NOM) is the progestogenic component. Progesterone receptor membrane component 1 (PGRMC1) is highly expressed in the tissue of
[Nomegestrol acetate in contraception and venous thrombotic risk].
C Jamin
Gynecologie, obstetrique & fertilite, 40(7-8), 394-395 (2012-07-04)
Multiple sclerosis and progestins: a comment to POPART'MUS.
Helmut Leitner
Journal of the neurological sciences, 300(1-2), 198-198 (2010-11-03)
Mireille G F Gerrits et al.
Contraception, 87(2), 193-200 (2012-08-18)
The pharmacokinetics of the monophasic oral contraceptive nomegestrol acetate (NOMAC) plus 17β-estradiol (E(2)) were investigated after a single dose and multiple dosing. NOMAC/E2 (2.5 mg/1.5 mg) was administered daily to healthy women (18-50 years, n=23) for 24 days; blood samples
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