SML0151
CCT036477
≥98% (HPLC)
别名:
α-(4-Chlorophenyl)-2-methyl-N-2-pyridinyl-1H-indole-3-methanamine
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关于此项目
经验公式（希尔记法）:
C21H18ClN3
化学文摘社编号:
分子量:
347.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
CCT036477, ≥98% (HPLC)
InChI
1S/C21H18ClN3/c1-14-20(17-6-2-3-7-18(17)24-14)21(15-9-11-16(22)12-10-15)25-19-8-4-5-13-23-19/h2-13,21,24H,1H3,(H,23,25)
SMILES string
Cc1[nH]c2ccccc2c1C(Nc3ccccn3)c4ccc(Cl)cc4
InChI key
IFOHRIXRQPOHQZ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥20 mg/mL (warm to 60°C)
storage temp.
−20°C
Quality Level
Biochem/physiol Actions
CCT036477 is an inhibitor of Wnt signaling. It does not alter β-catenin levels but blocks transcription at the β-catenin level. CCT036477 inhibited growth in several cancer cell lines and showed clear activity in vivo, blocking development of Zebrafish and Xenopus embryos and expression of Wnt target genes.
Wnt β-catenin antagonist
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Linwei Li et al.
PLoS genetics, 15(2), e1007996-e1007996 (2019-02-15)
Pharyngeal pouches, a series of outpocketings that bud from the foregut endoderm, are essential to the formation of craniofacial skeleton as well as several important structures like parathyroid and thymus. However, whether pharyngeal pouch progenitors exist in the developing gut
Rohit Mathur et al.
Journal of hematology & oncology, 8, 63-63 (2015-06-07)
Mantle cell lymphoma (MCL) is an aggressive and incurable form of non-Hodgkin's lymphoma. Despite initial intense chemotherapy, up to 50% of cases of MCL relapse often in a chemoresistant form. We hypothesized that the recently identified MCL-initiating cells (MCL-ICs) are
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