SML0176
Z36
≥98% (HPLC)
别名:
(Z)-5-Fluoro-1-(3′-dimethylamino)propyl-3-[(5′-methoxyindol-3-ylidene)methyl]-indolin-2-one, 1-[3-(dimethylamino)propyl]-5-fluoro-1,3-dihydro-3-[(5-methoxy-1H-indol-3-yl)methylene]-2H-Indol-2-one
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关于此项目
经验公式（希尔记法）:
C23H24FN3O2
化学文摘社编号:
分子量:
393.45
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
SMILES string
COc1ccc2[nH]cc(\C=C3/C(=O)N(CCCN(C)C)c4ccc(F)cc34)c2c1
InChI
1S/C23H24FN3O2/c1-26(2)9-4-10-27-22-8-5-16(24)12-19(22)20(23(27)28)11-15-14-25-21-7-6-17(29-3)13-18(15)21/h5-8,11-14,25H,4,9-10H2,1-3H3/b20-11-
InChI key
CQNOITUXWKRVMB-JAIQZWGSSA-N
assay
≥98% (HPLC)
form
powder
color
light yellow to dark yellow
solubility
DMSO: ≥15 mg/mL
storage temp.
−20°C
Quality Level
Application
Z36 may be used to study cell signaling that results in autophagy.
Biochem/physiol Actions
Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis
Z36 inhibits cell proliferation and induces death in HeLa cells. The cell death induced is via autophagy and autophagic flux.
Z36 is a Bcl-XL inhibitor that induces autophagic cell death independent of apoptosis which distinguishes it from other Bcl-XL and Bcl-2 inhibitors that induce cancer cell death mainly through apoptosis. Z36 binds to the BH3 binding groove of BCL-XL where it is thought to induce autophagy through blocking the interaction between Bcl-XL/Bcl2 and Beclin 1.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Jian Lin et al.
Autophagy, 5(3), 314-320 (2009-02-27)
Inhibition of Bcl2 family proteins Bcl-X(L) and Bcl-2 represents a promising drug development strategy for cancer treatment by triggering apoptosis in cancer cells. Here we report a novel Bcl-X(L) inhibitor, Z36, which unexpectedly induces only autophagic cell death, but not
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