SML0178

ARL-17477 dihydrochloride hydrate

Name: ARL-17477 dihydrochloride hydrate
Brand: SIGMA

≥98% (HPLC)

别名:

N-[4-[2-[[(3-chlorophenyl)methyl]amino]ethyl]phenyl]-2-thiophenecarboximidamide dihydrochloride hydrate

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关于此项目

经验公式（希尔记法）:

C₂₀H₂₀ClN₃S·2HCl · xH₂O

化学文摘社编号:

866914-87-6

分子量:

442.83 (anhydrous basis)

NACRES:

NA.77

PubChem Substance ID:

329825207

UNSPSC Code:

12352202

MDL number:

MFCD21608518

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InChI

1S/C20H20ClN3S.2ClH.H2O/c21-17-4-1-3-16(13-17)14-23-11-10-15-6-8-18(9-7-15)24-20(22)19-5-2-12-25-19;;;/h1-9,12-13,23H,10-11,14H2,(H2,22,24);2*1H;1H2

SMILES string

O.Cl.Cl.Clc1cccc(CNCCc2ccc(NC(=N)c3cccs3)cc2)c1

InChI key

QOPATWWWZNTSQF-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to beige

solubility

H₂O: ≥5 mg/mL

originator

AstraZeneca

storage temp.

2-8°C

Quality Level

100

Application

ARL-17477 dihydrochloride hydrate may be used in cell signaling studies.

Biochem/physiol Actions

ARL-17477 dihydrochloride hydrate is a selective nNOS inhibitor

ARL-17477 is an nNOS specific inhibitor. The IC₅₀ against rat nNOS is 35 nM and it has 100-fold selectivity over endothelial and inducible isoforms. ARL-17477 penetrates the brain, and reduces infarct size and reduces cerebral blood flow in several different rodent models of ischemic brain injury.