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Merck
CN

SML0181

Sigma-Aldrich

S 17092

≥98% (HPLC)

别名:

(2S,3aS,7aS)-1-(((R,R)-2-Phenylcyclopropyl)carbonyl)-2-((thiazolidin-3-yl)carbonyl)octahydro-1H-indole, [(2S,3aS,7aS)-Octahydro-1-[[(1R,2R)-2-phenylcyclopropyl]carbonyl]-1H-indol-2-yl]-3-thiazolidinyl--methanone

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关于此项目

经验公式（希尔记法）:
C22H28N2O2S
化学文摘社编号:
176797-26-5
分子量:
384.53
MDL编号:
MFCD00948255
UNSPSC代码:
12352200
PubChem化学物质编号:
329825210
NACRES:
NA.77

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方案

≥98% (HPLC)

表单

powder

旋光性

[α]/D -140 to -170° in dichloromethane

颜色

white to tan

溶解性

DMSO: ≥10 mg/mL

储存温度

2-8°C

SMILES字符串

O=C([C@@H]1C[C@@H]2CCCC[C@@H]2N1C(=O)[C@@H]3C[C@H]3c4ccccc4)N5CCSC5

InChI

1S/C22H28N2O2S/c25-21(18-13-17(18)15-6-2-1-3-7-15)24-19-9-5-4-8-16(19)12-20(24)22(26)23-10-11-27-14-23/h1-3,6-7,16-20H,4-5,8-14H2/t16-,17-,18+,19-,20-/m0/s1

InChI key

NXSXRIHXEQSYEZ-KNJMJIDISA-N

相关类别

应用

S 17092 may be used in prolyl endopeptidase-mediated cell signaling studies.

生化/生理作用

Potent selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Nootropic.
S-17092 is a potent, selective inhibitor of Prolyl oligopeptidase (POP), also known as prolyl endopeptidase (PEP or PE). Ki=1.5 nM. Nootropic.

S-17092 inhibition of POP prevents breakdown and thus increases the activity of a number of neuropeptides, which is likely the basis for its nootropic activity. S 17092 has been shown to improve cognition. It improved cognitive task performance in chronic low dose MPTP-treated monkeys. S-17092 was recently used to inhibit the formation of AcSDKP from its precursor 43-mer thymosin ?4 (T?4). Ac-SDKP is involved in hemopoietic stem cell differentiation, is pro-angiogenic and antifibrogenic.

特点和优势

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

象形图

Exclamation mark
GHS07

警示用语：

Warning

危险声明

H302

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000219878
0000219878
0000137292
0000078573
0000054448

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Sokrates Stein et al.
Cardiovascular research, 117(4), 1060-1069 (2020-05-14)
Fibroblast activation protein (FAP) is upregulated at sites of tissue remodelling including chronic arthritis, solid tumours, and fibrotic hearts. It has also been associated with human coronary atherosclerotic plaques. Yet, the causal role of FAP in atherosclerosis remains unknown. To
Tommi P Kilpeläinen et al.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 128, 110253-110253 (2020-05-25)
Previous studies have shown that prolyl oligopeptidase (PREP) negatively regulates autophagy and increases the aggregation of alpha-synuclein (αSyn), linking it to the pathophysiology of Parkinson's disease. Our earlier results have revealed that the potent small molecular PREP inhibitor KYP-2047 is
Hypothalamic prolyl endopeptidase (PREP) regulates pancreatic insulin and glucagon secretion in mice.
Kim JD, Toda C, D'Agostino G, et al.
Proceedings of the National Academy of Sciences of the USA, 111(32), 11876-11881 (2014)

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