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Merck
CN

SML0184

人参皂苷 Rg3

≥98% (HPLC), MAPK activation, powder

别名:

(3β, 12β）-12,20-二羟基 dmar-24-烯-3-基 2- O -β- D -吡喃葡萄糖基-β- D -吡喃葡萄糖苷, 20 (S)-人参皂苷-Rg3, Rg3

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关于此项目

经验公式（希尔记法）:
C42H72O13
化学文摘社编号:
14197-60-5
分子量:
785.01
UNSPSC Code:
12352200
PubChem Substance ID:
329825213
NACRES:
NA.77
MDL number:
MFCD06410950

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产品名称

人参皂苷 Rg3, ≥98% (HPLC)

SMILES string

C\C(C)=C\CC[C@](C)(O)[C@H]1CC[C@]2(C)[C@@H]1[C@H](O)C[C@@H]3[C@@]4(C)CC[C@H](O[C@@H]5O[C@H](CO)[C@@H](O)[C@H](O)[C@H]5O[C@@H]6O[C@H](CO)[C@@H](O)[C@H](O)[C@H]6O)C(C)(C)[C@@H]4CC[C@@]23C

InChI

1S/C42H72O13/c1-21(2)10-9-14-42(8,51)22-11-16-41(7)29(22)23(45)18-27-39(5)15-13-28(38(3,4)26(39)12-17-40(27,41)6)54-37-35(33(49)31(47)25(20-44)53-37)55-36-34(50)32(48)30(46)24(19-43)52-36/h10,22-37,43-51H,9,11-20H2,1-8H3/t22-,23+,24+,25+,26-,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-,37-,39-,40+,41+,42-/m0/s1

InChI key

RWXIFXNRCLMQCD-JBVRGBGGSA-N

assay

≥98% (HPLC)

form

powder

optical activity

[α]/D +10 to +20°, c = 1 in methanol

storage condition

desiccated

color

white to beige

solubility

DMSO: ≥5 mg/mL

storage temp.

2-8°C

Quality Level

100

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相关类别

Application

人参皂苷 Rg3 可能用于细胞信号传导研究。
人参皂苷 Rg3 用于研究其对长QT综合征（LQTS）2-人诱导多能干细胞（hiPSC-CM）中延迟整流钾电流（IKr）通道的调控作用。

Biochem/physiol Actions

人参皂苷 Rg3 是从 人参中分离得到的天然产物 。与其他人参皂甙相似，它具有心脏保护作用。人参皂甙 Rg3 通过与通道孔入口的相互作用增强心脏、hERG (IKr) 和 KCNQ (Iks) 通道电流。它还通过调节 p44/42 MAPK 活化抑制棕榈酸酯诱导的 MIN6N8 小鼠胰岛素瘤 β 细胞凋亡。人参皂苷 Rg3 提高转录因子 Nrf2 的级别，诱导多药耐药相关蛋白 (Mrp) 1 和 Mrp3 的 mRNA 水平。Rg3 通过减弱小胶质细胞对全身 LPS 处理的反应来调节神经炎症。它激活 HepG2 细胞中的 AMPK，减少脂质蓄积，从而降低血脂异常导致的心血管疾病风险。

Features and Benefits

该化合物在受体分类和信号转导手册的钾通道页面上有重点介绍。想要浏览手册的其他页面， 请单击此处。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000509867
0000509867
0000479226
0000479225
0000479225

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Sang Il Gum et al.
Oxidative medicine and cellular longevity, 2013, 957947-957947 (2013-06-15)
Previously, we found that Korean red ginseng suppressed acetaminophen (APAP)-induced hepatotoxicity via alteration of its metabolic profile involving GSTA2 induction and that ginsenoside Rg3 was a major component of this gene induction. In the present study, therefore, we assessed the
Seohyun Lee et al.
International journal of molecular sciences, 13(5), 5729-5739 (2012-07-04)
Cardiovascular disease (CVD) is one of the main causes of mortality worldwide, and dyslipidemia is a major risk factor for CVD. Ginseng has been widely used in the clinic to treat CVD. Ginsenoside Rg3, one of the major active components
J-P Liu et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(10), 3388-3396 (2012-07-24)
The purpose of this study is to investigate the potential subchronic toxicity of 20(S)-Ginsenoside Rg3(Rg3), by a 26-week repeated intramuscular administration in rats. Rg3 was administrated to rats at dose levels of 0, 4.2, 10.0 or 20.0 mg/kg/day. There was
Dongsun Park et al.
Environmental toxicology and pharmacology, 31(3), 397-405 (2011-07-27)
Antitumor effects of a ginsenoside Rg(3)-fortified red ginseng preparation (Rg(3)-RGP) were investigated in human non-small cell lung carcinoma (H460) cells using in vitro cytotoxicity assay and in vivo nude mouse xenograft model. Immunomodulatory effects of the preparation were also assessed
Jin-Kwang Kim et al.
Food chemistry, 141(2), 1369-1377 (2013-06-26)
The ginsenoside Rg3(S), which is one of the exceptional components of Korean red ginseng extract, has been known to have anti-cancer, anti-metastatic, and anti-obesity effects. An enzymatic bioconversion method was developed to obtain the ginsenoside Rg3(S) with a high specificity
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