ML133 盐酸盐

Name: ML133 盐酸盐
Brand: SIGMA

≥95% (HPLC)

别名:

1-(4-methoxyphenyl)-N-(naphthalen-1-ylmethyl)methanamine hydrochloride, CID 781301 hydrochloride, N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride, SID 85281105 hydrochloride, VU0404943-1 hydrchloride

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About This Item

经验公式（希尔记法）:

C₁₉H₁₉NO · HCl

CAS Number:

1222781-70-5

分子量:

313.82

MDL编号:

MFCD20921521

UNSPSC代码:

12352200

PubChem化学物质编号:

329825217

NACRES:

NA.77

质量水平

100

方案

≥95% (HPLC)

表单

powder

储存条件

desiccated

颜色

white to tan

溶解性

DMSO: ≥10 mg/mL

储存温度

2-8°C

SMILES字符串

Cl.COc1ccc(CNCc2cccc3ccccc23)cc1

InChI

1S/C19H19NO.ClH/c1-21-18-11-9-15(10-12-18)13-20-14-17-7-4-6-16-5-2-3-8-19(16)17;/h2-12,20H,13-14H2,1H3;1H

InChI key

NGQIBUUFXDPHKT-UHFFFAOYSA-N

应用

ML133 hydrochloride has been used as a Kir2.1 blocker to study the regulation of membrane excitability by inward-rectifier potassium channels (Kir2 family) in the dentate gyrus (DG) granule cells. It has also been used to study the effect of Kir2 on cortical neural activity.

ML133 hydrochloride may be used to study cell signaling that involves the function of potassium channels.

生化/生理作用

Inhibitor of Kir2 family channels

ML133 hydrochloride is a selective inhibitor of the Kir2 family of inward rectifier (IRK, KCNJ) potassium channels. ML133 inhibits Kir2.1 with IC50 of 1.8 μM at pH 7.4 and 290 nM at pH8.5. It exhibits little selectivity against other members of Kir2.x family channels, but has no effect on Kir1.1 (IC50 > 300 μM), and displays weak activity for Kir4.1 (76 μM) and Kir7.1 (33 μM), making ML133 the most selective small molecule inhibitor of the Kir family reported to date. It also showed modest selectivity versus hERG and a larger panel of GPCRs, ion channels and transporters.

特点和优势

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.